中国临床药理学杂志2023，Vol.39Issue(24)：3669-3673,5.DOI:10.13699/j.cnki.1001-6821.2023.24.027
艾司氯胺酮对重要器官保护研究现状
Research status of protection of important organs by esketamine
摘要
Abstract
Esketamine mainly acts by noncompetitively antagonizing the N-methyl-D-aspartate receptor,and as a dextral isomer of ketamine,it is widely used in clinical practice,especially in anti-inflammatory,analgesic,neuroprotective and other aspects.Esketamine not only has neuroprotective effects,but also has certain organ protective effects.In recent years,more and more studies have shown that ketamine can alleviate organ reperfusion injury by inhibiting cell apoptosis,improving cell damage,and regulating signaling pathways.This article reviews the protective effects and mechanisms of esketamine on the heart,brain,liver and lungs,providing a clinical theoretical basis for the clinical application of esketamine.关键词
艾司氯胺酮/器官保护/缺血再灌注损伤Key words
esketamine/organ protection/ischemia reperfusion injury分类
医药卫生引用本文复制引用
李森,蓝金辛,杨铎,何俊冰,张隆盛..艾司氯胺酮对重要器官保护研究现状[J].中国临床药理学杂志,2023,39(24):3669-3673,5.基金项目
广东省自然科学基金资助项目(2022A1515012413) （2022A1515012413）
广东省医学科学技术研究基金资助项目(B2022294) （B2022294）
广东省中医药局面上科研基金资助项目(20191409,20201463) （20191409,20201463）
