中国临床药理学杂志2024，Vol.40Issue(1)：82-86,5.DOI:10.13699/j.cnki.1001-6821.2024.01.017
清热消炎宁片重复给药的毒理学研究
Toxicology study on repeated administration of Qingre Xiaoyanning tablets
摘要
Abstract
Objective To explore the effect of Qingre Xiaoyanning tablets on chronic toxicity in SD rats.Methods A total of 120 SD rats were randomly divided into blank group(water)and experimental-L,-M,-H groups(2.63,5.25 and 10.50 g·kg 1 Qingre Xiaoyanning dry paste powder),with 30 rats per group.Four groups were administered continuously for 4 weeks with a recovery period of 4 weeks.SD rats were dissected as planned.The general condition,weight gain,hematological and biochemical indexes,major organ coefficients,macroscopic and microscopic tissue morphology were observed.Results There were no significant differences in the general condition,body mass growth,coagulation index and histopathology of rats between the experimental-L,-M,-H groups and the blank group.End of administration,the mean hemoglobin concentrations of experimental-H and blank groups were(370.70±3.78)and(365.90±5.77)g·L-1,glucose were(5.98±0.63)and(6.61±0.93)mmol·L-1,blood urea nitrogen(BUN)were(4.72±1.01)and(5.78±1.64)mmol·L-1,liver coefficients were 3.05±0.17 and 2.89±0.19,and the differences were statistically significant(P≤0.05,P≤0.01).Resumption of the final,direct bilirubin of experimental-L and blank groups were(0.38±0.18)and(0.19±0.18)pmol·L 1,BUN of experimental-M and blank groups were(4.45±0.56)and(5.65±1.16)mmol·L-1,and the differences were statistically significant(all P≤0.05).Conclusion Repeated administration of Qingre Xiaoyanning tablets showed no significant toxicity in SD rats.关键词
清热消炎宁片/干膏粉/大鼠/重复给药/毒性试验Key words
Qingre Xiaoyanning tablet/dry paste powder/rat/repeated administration/toxicity study分类
医药卫生引用本文复制引用
赵莉,扶丽君,周芷伊,易帅,王衡新..清热消炎宁片重复给药的毒理学研究[J].中国临床药理学杂志,2024,40(1):82-86,5.基金项目
湖南省重点研发计划基金资助项目(2023SK2080) （2023SK2080）
