中国临床药理学杂志2024，Vol.40Issue(1)：87-91,5.DOI:10.13699/j.cnki.1001-6821.2024.01.018
三七多糖体内抗疲劳研究
Experimental study on anti-fatigue effect of Polysaccharides of Panax notoginseng
摘要
Abstract
Objective To explore the effect of Polysaccharides of Panax notoginseng(PPN)on anti-exercise fatigue in mice.Methods One hundred male KM mice were randomly divided into negative control group,positive control group and experimental-L,-M,-H groups,with 20 cases per group.Experimental-L,-M,-H groups was given 100,200,400 mg·kg-1 PPN,respectively;positive control group was given 200 mg·kg-1 vitamin C;negative control group was given 0.1 mL·10 g-1 0.9％NaCl.Five groups were gavaged once a day for 28 days.After the last administration,the loaded swimming time was measured;after 90 minutes of the unloaded swimming test,the mice were allowed to rest for 30 minutes,the levels of lactic acid(LD),blood urea nitrogen(BUN),glycogen,and malondialdehyde(MDA)were measured,the safety of PPN with organ indices and histopathology.Results LD levels in negative control group,positive control group and experimental-L,-M,-Hgroupswere(4.76±0.84),(2.86±0.34),(3.00±0.69),(2.35±0.65)and(1.39±0.48)mg·kg-1;BUN contents were(13.65±1.25),(12.55±0.91),(12.12±1.24),(11.06±1.30)and(9.85±1.05)mmol·L-1;liver glycogen contents were(3.24±0.56),(11.11±2.16),(5.61±1.41),(6.60±1.49)and(12.05±2.25)mg·g-1;MDA levels were(2.36±0.21),(1.23±0.41),(1.93±0.23),(1.73±0.21)and(1.04±0.18)mg prot·mL-1.Compared with negative control group,the differences of above indexes in the positive control group and experimental-L,-M,-H groups were statistically significant(P＜0.05,P＜0.01,P＜0.001).Conclusion PPN can increase exercise endurance in mice and has an anti-fatigue effect.This study provides a theoretical basis for the application of PPN in the field of anti-fatigue research.关键词
三七多糖/运动疲劳/负重游泳/非负重游泳/抗疲劳Key words
polysaccharides of Panax notoginseng/exercise fatigue/the loaded swimming/the unloaded swimming/anti-fatigue分类
医药卫生引用本文复制引用
位盼盼,晏子俊,邓萌玥,夏谍,丁俞珍,张磊,陈彤..三七多糖体内抗疲劳研究[J].中国临床药理学杂志,2024,40(1):87-91,5.基金项目
国家自然科学基金地区科学基金资助项目(81760698) （81760698）
第七批云南省高校工程研究中心立项建设基金资助项目([2019]-57) （[2019]-57）
