中国临床药理学杂志2024，Vol.40Issue(1)：135-138,4.DOI:10.13699/j.cnki.1001-6821.2024.01.028
肾溶质清除率增加高发疾病动物模型建立研究
Establishment of animal model of increased renal solute clearance
杨舒 1罗轶凡 2初阳1
作者信息
- 1. 中国医科大学第一临床学院,辽宁沈阳 110001
- 2. 中国医科大学第一临床学院,辽宁沈阳 110001||中国医科大学附属第一医院药学部,辽宁沈阳 110001
- 折叠
摘要
Abstract
Clinically common patients with severe diseases such as sepsis,burns,subarachnoid hemorrhage,and traumatic brain injury have increased renal solute clearance,it's called augmented renal clearance(ARC).When such patients are given drugs that are excreted mainly by the kidneys,the drug does not reach effective therapeutic concentration levels,thereby increasing the risk of treatment failure.In recent years,this phenomenon has attracted more and more attention,but because its mechanism is not clear,it also limits the development of animal models for ARC research to a certain extent.Therefore,it is of great significance to establish corresponding animal models based on ARC-related risk factors for in-depth study of the mechanism of ARC occurrence.This article reviews the related animal models from the diseases with high incidence of clinical ARC,aiming to provide reference for the development of ARC animal models.关键词
肾溶质清除率增加/动物模型/脓毒症/烧伤/蛛网膜下腔出血/创伤性脑损伤Key words
augmented renal clearance/animal models/sepsis/burn/subarachnoid hemorrhage/traumatic brain injury分类
医药卫生引用本文复制引用
杨舒,罗轶凡,初阳..肾溶质清除率增加高发疾病动物模型建立研究[J].中国临床药理学杂志,2024,40(1):135-138,4.
