摘要
Abstract
Objective To study the clinical efficacy of carbocisteine tablets combined with salbutamol aerosol in the treatment of chronic obstructive pulmonary disease(COPD),and its effect on lung function and oxidative stress indexes.Methods COPD patients were divided into treatment group and control group.The control group was treated with salbutamol aerosol,and the treatment group was treated with carbocisteine tablets on the basis of the control group,0.5 g each time,3 times a day for 3 months.The pulmonary function,oxidative stress index,COPD self-assessment test(CAT)and serum inflammatory factor levels were compared between the two groups.Results After treatment,the forced expiratory volume in one second/forced vital capacity(FEV1/FVC)of the treatment group and the control group were(83.26±3.88)％and(75.12±3.87)％;forced vital capacity(FVC)were(3.67±0.31)and(3.11±0.22)L;forced expiratory volume in one second(FEV1)were(1.65±0.17)and(1.43±0.11)L·s-1;total antioxidant capacity(T-AOC)were(36.81±3.09)and(23.25±2.10)U·mL-1;glutathione peroxidase(GPX)were(73.49±3.45)and(53.13±3.55)nmol·L-1;malondialdehyde(MDA)were(12.74±1.14)and(10.09±1.10)nmol·mL-1;superoxide dismutase(SOD)levels were(328.30±16.96)and(462.44±17.73)U·mL-1;the subjective scores of CAT were 11.04±2.00 and 18.03±3.23;the motor index scores were 4.16±1.80 and 6.66±1.76;the serum interleukin-17(IL-17)levels were(29.39±2.38)and(40.90±2.80)pg·mL-1;tumor necrosis factor-α(TNF-α)were(31.96±2.04)and(40.04±2.57)pg·mL-1;the high-mobilitygroup box 1(HMGB1)levels were(41.50±3.03)and(72.23±4.63)pg·mL-1;the differences were all statistically significant(all P＜0.05).The incidence of adverse drug reactions in the treatment group and the control group was 10.53％and 20.00％,respectively,and the difference was not statistically significant(P＞0.05).Conclusion The combination of carbocisteine tablets and salbutamol aerosol in the clinical treatment of COPD can effectively improve the clinical efficacy,reduce inflammatory response,improve pulmonary function ventilation,and reduce oxidative stress.关键词
沙丁胺醇气雾剂/羧甲司坦片/慢性阻塞性肺疾病/氧化应激反应Key words
salbutamol aerosol/carbocisteine tablet/chronic obstructive pulmonary disease/oxidative stress response分类
医药卫生
