中国临床药理学杂志2024，Vol.40Issue(2)：185-189,5.DOI:10.13699/j.cnki.1001-6821.2024.02.007
肝动脉灌注化疗联合瑞戈非尼治疗结直肠癌肝转移患者的临床研究
Clinical trial of hepatic arterial infusion chemotherapy combined with regorafenib in the treatment of patients with liver metastasis of colorectal cancer
彭涛 1杨沔 1金梁斌 1沈雷斌1
作者信息
- 1. 宁波市医疗中心李惠利医院结直肠肛肠外科,浙江宁波 315000
- 折叠
摘要
Abstract
Objective To observe the short-term and long-term effects of hepatic artery infusion chemotherapy(HAIC)combined with regorafenib in the treatment of liver metastasis from colorectal cancer.Methods Patients with liver metastasis from colorectal cancer were reviewed.They were divided into treatment group and control group according to cohort method.The control group was treated with mFOLFOX6 HAIC chemotherapy regimen,and the experimental group was treated with 160 mg of regorafenib orally on the 1st to 21stday on the basis of the control group,28 days as a cycle.After 28 days of treatment,the short-term efficacy was evaluated.Tumor markers,liver function,long-term efficacy,and adverse drug reactions in the two groups were compared.Results There were 38 cases in the treatment group and 42 cases in the control group.The objective response rates of the treatment group and the control group were 26.32％and 9.52％;the disease control rates were 71.05％and 47.62％.After treatment,the levels of carcinoembryonic antigen in these two groups were(10.06±2.33)and(14.67±3.50)μg·L-1;the levels of carbohydrate antigen 199 in these two groups were(41.39±10.25)and(62.19±15.38)kU·L-1;the levels of carbohydrate antigen 242 in these two groups were(8.67±2.12)and(13.04±3.17)kU·L-1;the serum carbohydrate antigen 125 levels of these two groups were(36.52±9.18)and(45.22±9.01)kU·L-1.After treatment,the serum glutamic-oxalacetic transaminase levels in these two groups were(26.44±6.72)and(33.17±8.20)U·L-1;the levels of glutamic pyruvic transaminase in these two groups were(22.98±5.78)and(30.89±7.62)U·L-1.The median progression free survival time of these two groups was 3.7 and 2.7 months;the median overall survival time of these two groups was 11.7 and 9.4 months.The difference of the obove indicators between the treatment group and the control group were statistically significant(P＜0.05).The total incidence of adverse drug reactions in the treatment group and control group were 76.32％and 59.52％,with no statistically significant difference(P＞0.05).Conclusion HAIC combined with regorafenib can significantly improve the short-term efficacy in the treatment of liver metastasis from colorectal cancer,and prolong patient survival,with good clinical benefits.关键词
瑞戈非尼/肝动脉灌注化疗/结直肠癌/肝转移/疗效/肿瘤标志物Key words
regorafenib/hepatic artery infusion chemotherapy/colorectal cancer/liver metastasis/efficacy/tumor marker分类
医药卫生引用本文复制引用
彭涛,杨沔,金梁斌,沈雷斌..肝动脉灌注化疗联合瑞戈非尼治疗结直肠癌肝转移患者的临床研究[J].中国临床药理学杂志,2024,40(2):185-189,5.
