中国临床药理学杂志2024，Vol.40Issue(2)：284-288,5.DOI:10.13699/j.cnki.1001-6821.2024.02.028
中药活性成分调控Nrf2/HO-1信号通路防治糖尿病肾病的研究现状
Research status on the regulation of Nrf2/HO-1 signaling pathway by active ingredients of Chinese medicine in the prevention and treatment of diabetic kidney disease
摘要
Abstract
Diabetic kidney disease(DKD)is a high incidence microvascular complication caused by diabetes mellitus(DM).Persistent high glucose induces oxidative stress in the body.nuclear factor erythroid 2-related factor 2/heme oxygenase-1(Nrf2/HO-1)can play an anti-inflammatory and anti-oxidative role by inhibiting the accumulation of extracellular matrix in glomerular mesangium,inhibiting epithelial-mesenchymal transition in renal tubular epithelial cells,and inhibiting iron apoptosis,so as to improve renal function damage and delay the process of DKD.This article reviews the relationship between Nrf2/HO-1 pathway and DKD and the effect of traditional Chinese medicine active ingredients on DKD through Nrf2/HO-1 signaling pathway,in order to provide a basis for the development of new drugs.关键词
中药活性成分/糖尿病肾病/核转录因子E2相关因子2/血红素加氧酶-1Key words
active ingredients of traditional Chinese medicine/diabetic kidney disease/nuclear factor erythroid 2-related factor 2/heme oxygenase-1分类
医药卫生引用本文复制引用
聂宵,王志刚,梁永林..中药活性成分调控Nrf2/HO-1信号通路防治糖尿病肾病的研究现状[J].中国临床药理学杂志,2024,40(2):284-288,5.基金项目
甘肃省教育厅产业支撑计划基金资助项目(2021CYZC-03) （2021CYZC-03）
