中国临床药理学杂志2024，Vol.40Issue(2)：289-293,5.DOI:10.13699/j.cnki.1001-6821.2024.02.029
脯氨酰羟化酶抑制药对肾保护作用的研究现状
Research status of kidney protection by proline hydroxylase inhibitors
摘要
Abstract
Targeted regulation of hypoxia inducible factor(HIF)pathway can provide therapeutic basis for inflammatory anemia,hypoxic nephropathy,cardiovascular diseases related to chronic kidney disease and other hypoxic diseases.At present,the first drug to act on the HIF pathway,roxadustat,has been used for the treatment of renal anemia,and other prolyl hydroxylase(PHD)inhibitors are also in clinical research.This article mainly reviews the various pathways and mechanisms of the protective effect of PHD inhibitors on the kidneys.关键词
脯氨酰羟化酶抑制药/低氧诱导因子/肾保护/作用机制Key words
prolyl hydroxylase inhibitor/hypoxia inducible factor/kidney protection/mechanism of action分类
医药卫生引用本文复制引用
胡月华,苏苗,陈强..脯氨酰羟化酶抑制药对肾保护作用的研究现状[J].中国临床药理学杂志,2024,40(2):289-293,5.基金项目
内蒙古自治区高等学校科学研究基金资助项目(NJZY19190) （NJZY19190）
包头医学院科学研究基金资助项目(BYJJ-ZRQM202226) （BYJJ-ZRQM202226）
