中国临床药理学杂志2024，Vol.40Issue(2)：294-298,5.DOI:10.13699/j.cnki.1001-6821.2024.02.030
靶向MDSCs免疫治疗结肠炎相关性癌症的研究现状
Research status in immunotherapy of colitis-related cancer with MDSCs
摘要
Abstract
Colitis-associated cancer(CAC)is a specific type of colorectal cancer that develops from inflammatory bowel disease(IBD).Myeloid-derived suppressor cells(MDSCs)are a group of myeloid cells with immunosuppressive properties,and MDSCs in the tumor microenvironment proliferate and activate during the development of colitis-associated cancer,inhibiting T-cell production and impairing their function,which impedes the immunotherapeutic effect of colitis-associated cancer.In this paper,we review the immunosuppressive mechanisms of MDSCs in the development of inflammatory bowel disease to colitis-associated cancers and the current drugs targeting MDSCs for immunotherapy of inflammatory colorectal cancers,with a view to providing new strategies for the treatment of colitis-associated cancers.关键词
结肠炎相关性癌症/髓源性抑制细胞/免疫治疗Key words
colitis-related cancer/myeloid-derived suppressor cells/immunotherapy分类
医药卫生引用本文复制引用
陈佳,夏琪,何钰洁,李悦,袁泽婷,殷佩浩..靶向MDSCs免疫治疗结肠炎相关性癌症的研究现状[J].中国临床药理学杂志,2024,40(2):294-298,5.基金项目
上海市普陀区卫生健康系统临床特色专科建设基金资助项目(2021tszk01) （2021tszk01）
