MR颅颈一体化高分辨血管壁成像定量分析在脑卒中相关血管床斑块负荷中应用OACSTPCD

Objective:To explore the application of high-resolution craniocervical vessel wall MR imaging in the quantita-tive analysis of carotid artery plaque burdens in stroke-related vascular beds.Methods:One hundred in-hospital patients with ischemic stroke from December 2018 to December 2020 were selected as study group,and 50 asymptomatic risk individuals and 50 healthy volunteers were enrolled as control group.All selected subjects underwent plain and contrast-enhanced high-resolution vessel wall MR imaging examinations.Parameters of the carotid vessel wall on the ischemic and non-ischemic sides of study group were recorded.The study group was further classified into good prognosis group and poor prognosis group ac-cording to the presence or absence of the brain death due to irreversible damages.Ischemic side carotid wall parameters of two subgroups were analyzed,and their predictive value for disease prognosis and correlation with the National Institutes of Health Stroke Scale(NIHSS)were also explored.The control group was followed up for two years,and further divided into dis-ease group and normal group according to the presence or absence of ischemic stroke.Carotid artery wall parameters and their predictive value were analyzed in both groups.Results:The lumen area of the ischemic side was smaller than that of non-ischemic side,and the total vessel area,wall area and mean normalized wall index were larger than those of non-is-chemic side(P<0.05).The lumen area of good prognosis group was larger than that of poor prognosis group,and the total ves-sel area,wall area and mean normalized wall index were smaller than those of poor prognosis group(P<0.05).The area under the receiver operating characteristic curve(AUC)of the combined test of carotid wall parameters for prognosis prediction in is-chemic stroke patients was the largest AUC(0.824).The lumen area was negatively correlated with NIHSS in study group(P<0.05).The lumen area of the disease group was smaller than that of normal group,and the total vessel area,wall area and mean normalized wall index were larger than those of normal group(P<0.05).The AUC of the combined test of carotid wall parameters for disease onset prediction in asymptomatic risk individuals was the largest AUC(0.838).Conclusion:Carotid artery wall parameters are of great value in detecting the prognosis of ischemic stroke and the incidence of ischemic stroke in asymptomatic risk population.Furthermore,patients with larger the lumen area suffer a more severe neurological injury.