摘要
Abstract
The type Ⅱ inflammatory response is primarily mediated by type 2 immune cells and cytokines,such as helper 2 cells(Th2)and group 2 innate lymphoid cells(ILC2),along with IL-4,IL-5 and IL-13.This response plays crucial roles in humoral immunity,parasite defense,toxin neutralization,tissue damage repair and regeneration.However,type-Ⅱ immune response can also contribute to the development of diseases.Currently,type Ⅱ inflammation is recognized to have physiological and pathological impli-cations in the skin,respiratory tract,digestive tract and adipose tissues.Moreover,it serves as a major cause of allergic diseases.Due to its unique immune microenvironment,the respiratory tract exhibits a high prevalence of type Ⅱ inflammation encompassing chronic sinusitis,allergic rhinitis,allergic asthma,allergic bronchopulmonary aspergillosis,and chronic obstructive pulmonary disease with eosinophilia among others.This review will focus on the research progress concerning Th2 and ILC2 cells in allergic pulmonary inflam-mation as well as targeted therapy for allergic diseases.关键词
二型辅助型T细胞/二型先天样淋巴细胞/肺部过敏性炎症Key words
Th2/ILC2/Allergic pulmonary inflammation分类
医药卫生
