中国免疫学杂志2024，Vol.40Issue(1)：178-184,7.DOI:10.3969/j.issn.1000-484X.2024.01.028
纳米抗体在自身免疫性疾病中的应用
Application of nanobodies in autoimmune diseases
摘要
Abstract
Autoimmune disease is a kind of heterogeneous disease caused by the loss of immune tolerance to autoantigens.In recent years,antibody drug has become an important choice for the treatment of autoimmune diseases.Monoclonal antibodies are limited by their large relative molecular mass and difficult to penetrate solid tissues,while nanobodies,the smallest antibody fragment known to date with intact antigen recognition,have gained much attention in the treatment of autoimmune diseases due to their ease of modifi-cation,high penetration,and ability to target more cryptic epitopes.The review focuses on the application of nanobodies in the treat-ment of diseases such as rheumatoid arthritis,acquired thrombotic thrombocytopenic purpura,systemic lupus erythematosus,psoria-sis,and looks forward to the prospect of nanobodies in the treatment of autoimmune diseases.关键词
纳米抗体/自身免疫性疾病/细胞因子Key words
Nanobody/Autoimmune diseases/Cytokines分类
医药卫生引用本文复制引用
敖正宏,王玥,梅雅贤,罗文新..纳米抗体在自身免疫性疾病中的应用[J].中国免疫学杂志,2024,40(1):178-184,7.基金项目
国家自然科学基金项目(32070940). （32070940）
