中国人兽共患病学报2023，Vol.39Issue(12)：1151-1157,1195,8.DOI:10.3969/j.issn.1002-2694.2023.00.149
加利地韦对狂犬病病毒体外抑制作用研究
Inhibitory effects of Galidesivir(BCX4430)on rabies virus in vitro
谢渊 1迟瑛琳 1陶晓燕 1于鹏程 1刘茜 1刘淑清 1朱武洋1
作者信息
- 1. 中国疾病预防控制中心病毒病预防控制所,卫健委生物安全重点实验室,北京 102206
- 折叠
摘要
Abstract
This study analyzed the inhibitory effects of BCX4430 on rabies virus with different virulence(CVS-11 and SC16)in vitro.Direct immunofluorescence(DFA),quantitative real-time PCR and half tissue culture infective dose(TCID50)assays were used.BCX4430(250 pmol/L),compared with T-705,significantly decreased the viral titer and the relative expres-sion level of viral mRNA,similarly to the inhibitory effects of ribavirin.Thus,our study demonstrated that BCX4430 signifi-cantly inhibits the replication of rabies virus in vitro.关键词
加利地韦/狂犬病病毒/体外抑制作用Key words
Galidesivir(BCX4430)/rabies virus/inhibitory effects in vitro分类
医药卫生引用本文复制引用
谢渊,迟瑛琳,陶晓燕,于鹏程,刘茜,刘淑清,朱武洋..加利地韦对狂犬病病毒体外抑制作用研究[J].中国人兽共患病学报,2023,39(12):1151-1157,1195,8.
