中国人兽共患病学报2023，Vol.39Issue(12)：1202-1210,9.DOI:10.3969/j.issn.1002-2694.2023.00.146
α疱疹病毒囊膜糖蛋白gI影响病毒毒力的分子机制
Molecular mechanism of the effects of alphaherpesvirus envelope glycoprotein I on virulence
摘要
Abstract
The alphaherpesvirus envelope glycoprotein I,encoded by the non-essential gene US7,plays an important role in the pathogenic mechanism of the virus.Recent studies have shown that envelope glycoprotein gI is important in the assembly of alpha herpesvirus particles and the diffusion of viral particles,by participating in secondary envelope coating and promoting in-tercellular transmission.The protein also has essential roles in promoting the axonal transport of the virus along neurons and the anti-host immune response,thereby affecting virulence.This article discusses the molecular mechanism through which gI affects the virulence of alpha herpes virus,thus providing a theoretical basis for in-depth study of the function of this protein.关键词
α疱疹病毒/囊膜糖蛋白gI/病毒毒力Key words
alphaherpesvirus/glycoprotein I/viral virulence分类
医药卫生引用本文复制引用
庞玉莲,秦旭东,汪铭书,程安春..α疱疹病毒囊膜糖蛋白gI影响病毒毒力的分子机制[J].中国人兽共患病学报,2023,39(12):1202-1210,9.基金项目
国家自然科学基金(No.32072894)、财政部和农业农村部国家现代农业产业技术体系专项(No.CARS-42-17)和国家农业产业技术体系四川兽药创新团队专项(No.SCCXTD-2021-18)联合资助Supported by the National Natural Science Foundation of China(No.32072894),the earmarked fund for China Agriculture Re-search System(No.CARS-42-17),and the Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricul-tural Research System(No.SCCXTD-2020-18). （No.32072894）
