中国人兽共患病学报2023，Vol.39Issue(12)：1211-1217,7.DOI:10.3969/j.issn.1002-2694.2023.00.138
黏菌素耐药基因mcr-1的研究进展
Research progress in the colistin resistance gene mcr-1
摘要
Abstract
Polymyxin antibiotics,particularly polymyxin B and polymyxin E(colistin),are often considered a last line of defense against penicillin carbapenem-resistant Enterobacteriaceae(CRE),because of their favorable clinical antibacterial effects.However,the emergence and spread of plasmid-mediated colistin resistance genes(mcr),and their multiple isoforms,have posed a substantial threat to public health in recent years.The mcr-1 genes exhibit complexity in both host and transmis-sion routes,and diversity in both the genetic environment and ecological locus distribution.Herein,we discuss the prevalence,transmission routes,drug resistance and transmission mechanisms of mcr-1 positive isolates,on the basis of epidemiological studies of Enterobacteriaceae carrying mcr-1 worldwide.to provide a theoretical reference for researchers.关键词
黏菌素/mcr-1/流行情况/耐药机制/传播机制Key words
colistin/mcr-1/epidemic situation/resistance mechanism/transmission mechanism分类
医药卫生引用本文复制引用
朱琪琪,路宁宁,王承业,吴灵玉,张继瑜,朱阵,王玮玮..黏菌素耐药基因mcr-1的研究进展[J].中国人兽共患病学报,2023,39(12):1211-1217,7.基金项目
国家自然科学基金项目(No.32273068)与国家肉牛牦牛产业技术体系(No.CARS-37)联合资助Supported by the National Natural Science Foundation of China(No.32273068)and the earmarked fund for China Agriculture Research System(CARS)(No.CARS-37) （No.32273068）
