中国人兽共患病学报2023，Vol.39Issue(12)：1218-1225,8.DOI:10.3969/j.issn.1002-2694.2023.00.142
结核分枝杆菌ESX-1分泌系统与宿主巨噬细胞相互作用的研究进展
Research progress in the interaction between the Mycobacterium tuberculosis ESX-1 secretion system and host macrophages
摘要
Abstract
Mycobacterium tuberculosis(Mtb)invades and persists in host cells,thus facilitating pathogenicity.When Mtb infects the host,it interacts with host macrophages(Mø)and regulates Mø function,thereby influencing the body's innate and adaptive immune response.The ESX-1 secretion system,the main secretion system of Mtb,transports secreted proteins into host cells,where they exert virulence and immune regulation;some secreted proteins are highly immunogenic and act as strongly effective T cell antigens—important antigens in tuberculosis vaccine design and tuberculosis diagnosis.Studying the mechanism of interaction between the ESX-1 secretion system and Mø enables analysis of the pathogenic mechanisms of Mtb virulence factors and aids in vaccine development.Therefore,this article reviews the composition of the ESX-1 secretion system of Mtb and the regulation of Mø by secreted proteins,and further analyzes the roles of ESX-1 secretion system factors in Mtb-host interactions.This understanding will be critical for the development of new vaccines and drugs to control TB.关键词
ESX-1分泌系统/巨噬细胞/结核分枝杆菌Key words
ESX-1 secretion system/macrophage/Mycobacterium tuberculosis分类
医药卫生引用本文复制引用
余海燕,杨国平..结核分枝杆菌ESX-1分泌系统与宿主巨噬细胞相互作用的研究进展[J].中国人兽共患病学报,2023,39(12):1218-1225,8.基金项目
云南省地方本科高校联合专项面上项目(No.2017FH001-085) （No.2017FH001-085）
大理大学高层次人才资助项目(No.KYBS201708) （No.KYBS201708）
大理大学临床分子免疫学创新团队(No.ZKLX2019105).Supported by the Yunnan Provincial Joint Undergraduate Program(No.2017FH001-085),the High-level Talents of Dali Uni-versity(No.KYBS201708),and the Clinical Molecular Immunology Innovation Team of Dali University(No.ZKLX2019105) （No.ZKLX2019105）
