中国实验动物学报2023，Vol.31Issue(12)：1610-1616,7.DOI:10.3969/j.issn.1005-4847.2023.12.012
应用基因修饰动物模型研究抑郁症进展
Progress in depression research using genetically modified animal models
摘要
Abstract
Depression is a complex mental disease with polygenic inheritance and a high incidence.Our understanding of the clinical manifestations and pathogenesis of depression has recently improved.Continuous progress in gene-editing technologies has increased the construction efficiency and reduced the cost of gene-knockout animals,leading to their increasing use in the fields of basic research and drug development for depression and providing a powerful tool for revealing the pathogenesis of depression.In this review,we summarize recent progress in understanding the roles and mechanisms of candidate genes in depression using knockout model mice.关键词
抑郁症/基因敲除/单胺能系统/脑源性神经营养因子/谷氨酸/下丘脑-垂体-肾上腺轴Key words
depression/gene knockout/monoamine system/brain-derived neurotrophic factor(BDNF)/glutamic acid/HPA axis分类
生物科学引用本文复制引用
李梦瑶,高枫,郑帆帆,何盟泽,何昭,李优磊..应用基因修饰动物模型研究抑郁症进展[J].中国实验动物学报,2023,31(12):1610-1616,7.基金项目
陕西省教育厅科学研究计划项目(22JK0613),延安大学博士科研启动项目(YDBK2021-07). Funded by the Scientific Research Program of Shaanxi Provincial Education Department(22JK0613),Doctoral Research Program of Yan'an University(YDBK2021-07). （22JK0613）
