中国实验动物学报2023，Vol.31Issue(12)：1617-1628,12.DOI:10.3969/j.issn.1005-4847.2023.12.013
博来霉素诱导的肺纤维化动物模型研究进展
Progress in animal models of bleomycin-induced pulmonary fibrosis
摘要
Abstract
Pulmonary fibrosis(PF)is a progressive,interstitial fibrotic lung disease characterized by persistent scar formation in the lung parenchyma,and a reduced quality of life and poor prognosis for patients.The pathogenesis of PF is unknown and there is a lack of effective therapeutic agents;however,animal models are currently the main tool used to explore the pathogenesis of the disease and to find effective therapeutic agents.PF can be induced by various factors and to different degrees according to known etiologies.Among these,bleomycin-induced models are widely used because of their reproducibility and the similarity between the fibrosis pathology and clinical conditions.The main induction method include intratracheal drip,intratracheal nebulization,tail vein injection,intraperitoneal injection,and transnasal inhalation,and these can be classified into single and multiple doses,according to the frequency of induction.Based on the relevant literature,the current review summarizes the characteristics of the bleomycin-induced PF model using different induction frequencies and method,to provide a basis for the application of this model.关键词
肺纤维化/动物模型/博来霉素/造模方法Key words
pulmonary fibrosis/animal model/bleomycin/modeling method分类
生物科学引用本文复制引用
王搏,宋庆华,唐会猛,刘杨,谢洋,田燕歌..博来霉素诱导的肺纤维化动物模型研究进展[J].中国实验动物学报,2023,31(12):1617-1628,12.基金项目
河南省科技研发计划联合基金项目(232301420020),河南省自然科学基金资助项目(212300410056). Funded by Scientific and Technological Research and Development Plan of Henan Province(232301420020),National Natural Science Foundation of Henan(212300410056). （232301420020）
