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模式动物斑马鱼在人乳腺癌疾病研究中的应用进展

张敏 张晶晶 宁国柱

中国实验动物学报2023,Vol.31Issue(12):1629-1635,7.
中国实验动物学报2023,Vol.31Issue(12):1629-1635,7.DOI:10.3969/j.issn.1005-4847.2023.12.014

模式动物斑马鱼在人乳腺癌疾病研究中的应用进展

Research progress on the application of a zebrafish model in breast cancer research

张敏 1张晶晶 1宁国柱1

作者信息

  • 1. 广东医科大学附属医院湛江市斑马鱼发育与疾病动物模型重点实验室,广东 湛江 524001
  • 折叠

摘要

Abstract

The zebrafish xenograft model plays an important role in cancer modelling,especially breast cancer xenografts.This model facilitates the real-time observation of tumor cell growth,metastasis,and interactions with the immune system,thus providing novel insights and experimental foundations for breast cancer treatment.Furthermore,the zebrafish xenograft model offers a valuable tool for high-throughput drug screening.This review provides an overview of the contributions of the zebrafish xenograft model to elucidating the mechanisms underlying breast cancer development,and its use in screening anti-tumor drugs and conducting therapeutic research.

关键词

斑马鱼/异种移植模型/乳腺癌

Key words

zebrafish/xenotransplantation mode/breast cancer

分类

生物科学

引用本文复制引用

张敏,张晶晶,宁国柱..模式动物斑马鱼在人乳腺癌疾病研究中的应用进展[J].中国实验动物学报,2023,31(12):1629-1635,7.

基金项目

湛江市科技发展专项资金(2022A01231). Funded by the Science and Technology Planning Project of Zhanjiang(2022A01231). (2022A01231)

中国实验动物学报

OA北大核心CSCDCSTPCD

1005-4847

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