益生菌在儿童抗生素相关性腹泻应用进展OACSTPCD

Antibiotic-associated diarrhea(AAD)is a common complication of antibiotic treatment.It is characterized by the disruption of the gut microbiota,causing the decrease of intestinal short chain fatty acid(SCFA)concentrations,accumulation of luminal carbohydrates and colonic bile acids,changes in water and electrolyte absorption,and ultimately diarrhea.Many randomized controlled trials have shown the benefits of probiotics in preventing AAD.Although adverse events have been reported for probiotics,they still are broadly considered to be a safe and inexpensive preventative treatment option for AAD and other gastrointestinal disorders.This review summarized the effects of probiotics on children's AAD,in order to guide its rational application.