中国兽医杂志2023，Vol.59Issue(12)：94-98,5.
质谱技术用于细菌耐药性检测的研究进展
Advances in Mass Spectrometry Application in Bacterial Drug Resistance Detection
摘要
Abstract
Bacterial drug resistance hinders the efficacy of antimicrobial drugs,increases the risk of treatment failure for bacterial infections,and poses a threat to both animal and human health.Clearly defining bacterial resistance characteristics to guide clinical drug use is an effective means of combating drug-resistant bacterial infections.Currently,traditional susceptibility tests based on microbial culture suffer from issues such as cumbersome operation and long cycles.In contrast,mass spectrometry-based detection of bacterial drug resistance offers advantages such as speed,sensitivity,accuracy,high throughput,and minimal sample requirements,demonstrating great potential for widespread application.This article introduces two principles of mass spectrometry techniques applied to bacterial drug resistance detection:detection based on bacterial incubation with antibiotics and detection based on biomarkers of drug-resistant bacteria,and briefly describes their applications in human and veterinary clinical settings,as well as outlining the current trends and prospects for future development.关键词
质谱/细菌耐药性/检测Key words
mass spectrometry/bacterial drug resistance/detection分类
农业科技引用本文复制引用
段锻,江海洋,吴聪明..质谱技术用于细菌耐药性检测的研究进展[J].中国兽医杂志,2023,59(12):94-98,5.基金项目
国家重点研发计划(2020YFF01014605) （2020YFF01014605）
