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不同首发年龄精神分裂症患者临床特征及影响因素

杨凡刘波赵乐胜吴国平刘敏王延军王继才高长青卢瑾徐沛琳黄悦勤刘肇瑞张婷婷何燕玲章杰龚元东刘燕

中国心理卫生杂志2024，Vol.38Issue(1)：16-24,9.

中国心理卫生杂志2024，Vol.38Issue(1)：16-24,9.DOI:10.3969/j.issn.1000-6729.2024.01.003

不同首发年龄精神分裂症患者临床特征及影响因素

Clinical characteristics and related factors of patients with schizophrenia in different ages of onset

杨凡 ¹刘波 ²赵乐胜 ³吴国平 ⁴刘敏 ⁵王延军 ⁶王继才 ¹高长青 ⁶卢瑾 ¹徐沛琳 ⁷黄悦勤 ⁷刘肇瑞 ⁷张婷婷 ⁷何燕玲 ⁸章杰 ⁹龚元东 ¹⁰刘燕¹¹

作者信息

1. 昆明医科大学第一附属医院,昆明 650032
2. 荆州市精神卫生中心,湖北荆州 434000
3. 普洱市第二人民医院,云南普洱 665000
4. 楚雄州第二人民医院,云南楚雄 675000
5. 云南省玉溪市第二人民医院,云南玉溪 653100
6. 云南省精神病医院,昆明 650224
7. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京 100083
8. 上海市精神卫生中心,上海 200030
9. 中山市第三人民医院,中山市心理卫生中心,广东中山 528451
10. 山东省精神卫生中心,济南 250014
11. 济宁医学院,山东济宁 272013
折叠

摘要

Abstract

Objective:To explore the clinical characteristics and related socio-demographic factors of schizo-phrenia patients with different ages of onset.Methods:Totally 2 016 patients with schizophrenia aged 15 to 70 were selected according to the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition.All of the patients were interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview to diagnose schizophrenia,Clinical-Rated Dimensions of Psychosis Symptom Severity(CRDPSS)and the Positive and Negative Syndrome Scale(PANSS)to assess symptoms.The cut-off points were 18 and 25 years old for three age groups,i.e.early onset(EOS),youth onset(YOS)and adult onset(AOS).Statistical analy-ses were performed by analysis of variance Pearson correlation analysis,and multivariate linear regression.Results:The early-onset patients had the highest total PANSS score(73.8±28.0)and CRDPSS score(11.7±5.4).Fe-male gender,high education level,Han ethnicity,early onset age,and slower onset of illness were negatively corre-lated with the total and dimension score of PANSS scale and CRDPSS scale(standardized regression coefficient:0.04-0.47),and income level and smoking were negatively correlated with those score(standardized regression coefficient:-0.04--0.14).Conclusion:Early-onset schizophrenia patients have more severe symptoms,and fe-male,high education level,early-onset disease,and chronic onset are the risk factors of symptom severity in patients with schizophrenia.

关键词

精神分裂症/首发年龄/简明国际神经精神访谈/精神症状维度评定量表/阳性与阴性症状量表

Key words

schizophrenia/age of onset/Mini International Neuropsychiatric Interview/Clinical-Rated Di-mensions of Psychosis Symptom Severity/Positive and Negative Syndrome Scale

分类

医药卫生

引用本文复制引用

杨凡,刘波,赵乐胜,吴国平,刘敏,王延军,王继才,高长青,卢瑾,徐沛琳,黄悦勤,刘肇瑞,张婷婷,何燕玲,章杰,龚元东,刘燕..不同首发年龄精神分裂症患者临床特征及影响因素[J].中国心理卫生杂志,2024,38(1):16-24,9.

基金项目

国家重点研发计划(2017YFC0907800) （2017YFC0907800）

中国心理卫生杂志

OA北大核心CHSSCDCSTPCD

ISSN：1000-6729

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