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首发和复发抑郁症患者临床特征比较

郑秀艳章杰王海明封正敏郭俊陈文明姜林伶蔡德芳卢瑾唐诚霞刘肇瑞张婷婷黄悦勤周亮龚元东刘燕刘波

中国心理卫生杂志2024，Vol.38Issue(1)：25-32,8.

中国心理卫生杂志2024，Vol.38Issue(1)：25-32,8.DOI:10.3969/j.issn.1000-6729.2024.01.004

首发和复发抑郁症患者临床特征比较

Comparison of clinical characteristics between first-episode and relapse of major depressive disorder

郑秀艳 ¹章杰 ²王海明 ³封正敏 ⁴郭俊 ¹陈文明 ⁵姜林伶 ⁶蔡德芳 ¹卢瑾 ⁶唐诚霞 ⁶刘肇瑞 ⁷张婷婷 ⁷黄悦勤 ⁷周亮 ⁸龚元东 ⁹刘燕 ¹⁰刘波¹¹

作者信息

1. 云南省玉溪市第二人民医院,云南玉溪 653100
2. 中山市第三人民医院,中山市心理卫生中心,广东中山 528451
3. 云南省精神病医院,昆明 650224
4. 楚雄州第二人民医院,云南楚雄 675000
5. 普洱市第二人民医院,云南普洱 665000
6. 昆明医科大学第一附属医院精神科,昆明 650032
7. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京 100083
8. 广州医科大学附属脑科医院,广州 510370
9. 山东省精神卫生中心,济南 250014
10. 济宁医学院,山东济宁 272013
11. 荆州市精神卫生中心,湖北荆州 434000
折叠

摘要

Abstract

Objective:To describe demographic,clinical and physiological characteristics,treatment between first-episode major depressive disorder(MDD)and relapse MDD,and to explore characteristics of relapse MDD.Methods:Totally 858 patients who met the diagnostic criteria for depression of the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),were included by using the Mini International Neuropsychiatric Interview(MINI),Clinician-Rated Dimensions of Psychosis Symptom Severity,and Hamilton Depression Scale etc.Among them,529(58.6％)were first-episode depression and 329(36.0％)were relapsed.The differences of demographic characteristics,clinical and physiological characteristics,treatment were compared byx2test and Kruskal-Wallis rank sum test.Multivariate logistic regression was used to explore the characteristics of MDD recur-rence.Results:Compared to first-episode MDD,relapse MDD had more comorbidity(OR=2.11,95％CI:1.00-4.44),more days out of role(OR=1.26,95％CI:1.01-1.56),more history of using psychiatric drug more than one month(OR=1.41,95％CI:1.02-1.97)and electroconvulsive therapy(OR=3.23,95％CI:1.42-7.36),and higher waist-hip ratio(OR=33.88,95％CI:2.88-399.32).Conclusion:Relapse MDD has positive as-sociation with comorbidity of mental disorders,out of role,and higher waist-hip ratio.

关键词

抑郁症/首发/复发/临床特征

Key words

major depressive disorder/first-episode/relapse/clinical characteristics

分类

临床医学

引用本文复制引用

郑秀艳,章杰,王海明,封正敏,郭俊,陈文明,姜林伶,蔡德芳,卢瑾,唐诚霞,刘肇瑞,张婷婷,黄悦勤,周亮,龚元东,刘燕,刘波..首发和复发抑郁症患者临床特征比较[J].中国心理卫生杂志,2024,38(1):25-32,8.

基金项目

国家重点研发计划(2017YFC0907800).伦理批件号:(2018)伦审第(34)号（2017YFC0907800）

中国心理卫生杂志

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ISSN：1000-6729

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