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不同发病年龄的双相障碍患者的临床表现

马严龚元东付祥赵琼仙卢瑾沙万年合浩沈宗霖张婷婷陈文明田霄翌黄悦勤刘肇瑞邓咏妍周亮刘燕刘波章杰

中国心理卫生杂志2024，Vol.38Issue(1)：42-49,8.

中国心理卫生杂志2024，Vol.38Issue(1)：42-49,8.DOI:10.3969/j.issn.1000-6729.2024.01.006

不同发病年龄的双相障碍患者的临床表现

Comparison of clinically relevant factors in bipolar disorder patients with different age of onset

马严 ¹龚元东 ²付祥 ³赵琼仙 ⁴卢瑾 ⁵沙万年 ¹合浩 ⁶沈宗霖 ⁵张婷婷 ⁷陈文明 ¹田霄翌 ⁷黄悦勤 ⁷刘肇瑞 ⁷邓咏妍 ⁷周亮 ⁸刘燕 ⁹刘波 ¹⁰章杰¹¹

作者信息

1. 普洱第二人民医院,云南普洱 665000
2. 山东省精神卫生中心,济南 250014
3. 玉溪市第二人民医院,云南玉溪 653100
4. 楚雄州第二人民医院,云南楚雄 675000
5. 昆明医科大学第一附属医院精神科,昆明 650032
6. 云南省精神病医院,昆明 650224
7. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京 100083
8. 广州医科大学附属脑科医院,广州 510370
9. 济宁医学院,山东济宁 272013
10. 荆州市精神卫生中心,湖北荆州 434000
11. 中山市第三人民医院,中山市心理卫生中心,广东中山 528451
折叠

摘要

Abstract

Objective:To compare clinical characteristics,treatment patterns and physiological indicators in bipolar disorder(BD)patients with different age of onset.Methods:Totally 380 patients with DSM-5 BD were se-lected in this study.Psychiatrists diagnosed the patients using the Mini International Neuropsychiatric Interview.The clinical information questionnaire and the Global Assessment of Functioning scale were utilized to collected clinical characteristics,treatment status,and physiological indicators.The onset age of BD was divided into 21 and 35 years as cut-off points.Multivariate logistic regression and linear regression were used to analyze related factors.Results:Among the 380 patients with BD,199 cases were early-onset group(52.4％),121 cases were middle-onset group(31.8％),and 60 cases were late-onset group(15.8％).There were 26.6％of patients in the early-onset group in-itially diagnosed as depression,23.1％in the middle-onset group,and 11.7％in the late-onset group.Multivariate analysis revealed that compared to the early-onset group of BD,the middle-onset(OR=2.22)and late-onset(OR=4.99)groups had more risk to experience depressive episodes,and the late-onset group(OR=6.74)had 6.74 times of risk to suffer from bipolar Ⅱ disorder.Additionally,patients in the middle-onset(β=-1.52)and late-on-set(β=-4.29)groups had shorter durations of delayed treatment,and those in the middle-onset(β=-1.62)and late-onset(β=-3.14)groups had fewer hospitalizations.Uric acid levels were lower in both the middle-onset(β=-28.39)and late-onset(β=-31.47)groups,and total cholesterol level was lower in the middle-onset group(β=-0.23).Conclusion:Patients with BD in different age of onset show significant differences in clinical charac-teristics,treatment conditions and physiological indicators.

关键词

双相障碍/首发年龄/临床症状/生理指标/治疗

Key words

bipolar disorder/age of onset/clinical characteristics/physiological indicators/treatment

分类

医药卫生

引用本文复制引用

马严,龚元东,付祥,赵琼仙,卢瑾,沙万年,合浩,沈宗霖,张婷婷,陈文明,田霄翌,黄悦勤,刘肇瑞,邓咏妍,周亮,刘燕,刘波,章杰..不同发病年龄的双相障碍患者的临床表现[J].中国心理卫生杂志,2024,38(1):42-49,8.

基金项目

国家重点研发计划(2017YFC0907800) （2017YFC0907800）

中国心理卫生杂志

OA北大核心CHSSCDCSTPCD

ISSN：1000-6729

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