中国药房2024，Vol.35Issue(2)：214-218,5.DOI:10.6039/j.issn.1001-0408.2024.02.16
肾脏不适当用药对老年糖尿病患者衰弱的影响
The influence of renally inappropriate medication on the frailty of elderly patients with diabetes
摘要
Abstract
OBJECTIVE To investigate the effects of renally inappropriate medication(RIM)on the frailty of elderly patients with diabetes.METHODS The data of elderly patients with diabetes mellitus admitted to a third-grade class A hospital in Yunnan province from January to December 2022 were collected,and Beers criteria(2019 edition)and Chinese version of FRAIL scale were used to evaluate RIM and the frailty of the patients;the patients were divided into the trial group(with RIM)and the control group(without RIM)according to whether there was RIM.The propensity score matching was used to balance confounding factors between two groups,and the influence of RIM on the frailty of elderly diabetic patients was analyzed by the Logistic regression model.RESULTS Among the 367 patients,80 patients(21.80%)had RIM,the drugs involved RIM were spironolactone(82.56%),rivaroxaban(13.95%)and gabapentin(3.49%).After reaching the balance between groups using the propensity score matching method,the incidence of frailty was 77.94%in trial group and 27.94%in control group(P＜0.001);the difference was not statistically significant in other confounding factors between the two groups(P＞0.05).Results of Logistic regression analysis showed that the risk of frailty in the experimental group was 3.118 times that of the control group(odds ratio was 3.118,95%confidence interval was 1.758-5.530,P＜0.001).CONCLUSIONS RIM is a risk factor for the frailty of elderly patients with diabetes,which can be considered as an indicator for early identification and screening of the frailty of elderly diabetes patients.关键词
肾脏不适当用药/衰弱/老年/糖尿病/倾向性评分匹配法Key words
renally inappropriate medication/frailty/elderly/diabetes/propensity score matching分类
医药卫生引用本文复制引用
杨婉莹,周湘明,缪园园,赵云慧,王麓,柯亭羽,班立丽..肾脏不适当用药对老年糖尿病患者衰弱的影响[J].中国药房,2024,35(2):214-218,5.基金项目
云南省科技厅科技计划项目(No.202201AY070001-127) （No.202201AY070001-127）
云南省"高层次人才培养支持计划"名医专项(No.YNWR-MY-2020-022) （No.YNWR-MY-2020-022）
