中国医科大学学报2024，Vol.53Issue(1)：51-59,9.DOI:10.12007/j.issn.0258-4646.2024.01.009
基于SEER数据库的小肠腺癌患者预后的危险因素分析及预测模型构建
Prognostic risk factor analysis and prognosis prediction model construction for patients with small bowel adenocarcinoma based on the SEER database
摘要
Abstract
Objective To explore the risk factors affecting the prognosis of patients with small bowel adenocarcinoma(SBA),construct the SBA survival risk model,and evaluate the clinical predictive value.Methods Clinical information and prognosis data of 2 639 patients included in the surveillance,epidemiology,and end results(SEER)database were retrospectively analyzed.Overall survival(OS)and disease specific survival(DSS)were used as prognostic indicators.The training group and validation group were randomized at a 7 ∶ 3 ratio using univariate and multivariate Cox regression analysis.Prognostic factors affecting SBA sur-vival were screened,and a prognostic prediction model was constructed.The receiver operation characteristic curve,model valida-tion by validation group,and clinical decision curve.Results Age(P<0.01),tumor site(P = 0.018),size(P = 0.042),T stage(P<0.01),detection rate of positive lymph nodes(P<0.01),single tumor focus(P<0.01),and secondary liver metastasis(P<0.01)were independent risk factors affecting prognosis of OS in patients with SBA;age(P<0.01),tumor size(P= 0.022),T stage(P<0.01),detec-tion rate of positive lymph nodes(P<0.01),single tumor focus(P<0.01),and secondary liver metastasis(P<0.01)were independent risk factors affecting the prognosis of DSS in patients with SBA.The nomogram,survival risk assessment model,and calibration prediction curve were consistent with the actual curve.Conclusion Age,tumor size,T stage,detection rate of positive lymph nodes,single tumor focus,and secondary liver metastasis were independent risk factors for OS and DSS in patients with SBA.Tumor site was also an inde-pendent risk factor for OS in SBA patients.The established prognostic prediction model has good predictive value,can effectively evaluate the prognosis of SBA patients,and can provide reasonable treatment advice for patients.关键词
小肠腺癌/总生存期/疾病特异性生存期/预后预测模型Key words
small bowel adenocarcinoma/overall survival/disease specific survival/prognostic prediction model分类
医药卫生引用本文复制引用
袁维烨,肖先皓,宋禾..基于SEER数据库的小肠腺癌患者预后的危险因素分析及预测模型构建[J].中国医科大学学报,2024,53(1):51-59,9.基金项目
辽宁省自然科学基金(2023-MS-170) （2023-MS-170）
