中国医科大学学报2024，Vol.53Issue(2)：127-131,5.DOI:10.12007/j.issn.0258-4646.2024.02.006
血清糖蛋白非转移性黑色素瘤蛋白B对表皮生长因子受体扩增伴随突变的非小细胞肺癌预后的预测作用
Predictive value of serum glycoprotein non-metastatic melanoma protein B in patients with non-small cell lung cancer accompanied by epidermal growth factor receptor amplification with mutation
摘要
Abstract
Objective To evaluate the clinical value of free glycoprotein non-metastatic melanoma protein B(GPNMB)as a drug resis-tance and prognostic marker for non-small cell lung cancer(NSCLC)patients with epidermal growth factor receptor(EGFR)amplifica-tion accompanied by mutations.Methods Fifty-five cases of NSCLC patients with EGFR amplification associated with mutations who received treatment from March 2018 to September 2019 were included as the observation group.All patients received an EGFR-tyrosine kinase inhibitor(EGFR-TKI)as the first-line treatment;67 blood samples from the physical examination center during the same period were randomly included as healthy control.We compared the expression levels of free GPNMB between the two groups,explored the correlation between GPNMB expression and the clinicopathological information in the observation group;and combined the clinical efficacy to evaluate its value as a drug resistance marker.Through follow-up,the progress free survival(PFS)of patients was statistically analyzed,and through multivariate Cox regression analysis,independent risk factors affecting the survival in the observation group were explored.Results Compared with that in the control group,the expression level of free GPNMB in the observation group was signi-ficantly up-regulated.The expression level of free GPNMB in the observation group is significantly related to the clinical efficacy of EGFR-TKI(P = 0.016).Patients with high GPNMB expression have significantly stronger drug resistance,and patients with high GPNMB expression have significantly shorter PFS duration(P = 0.032).A high free GPNMB expression(HR = 4.029,95%CI:1.942-8.358,P＜0.001)is also an independent risk factor affecting patient survival.Conclusion The expression level of free GPNMB in patients with EGFR amplification accompanied by mutant NSCLC is significantly up-regulated,and its high expression is significantly related to the enhancement of the patient's drug resistance.High GPNMB expression is significantly related to the poor prognosis of patients and is an independent risk factor affecting patient survival.关键词
非小细胞肺癌/糖蛋白非转移性黑色素瘤蛋白B/表皮生长因子受体扩增伴随突变/耐药/预后Key words
non-small cell lung cancer/glycoprotein non-metastatic melanoma protein B/epidermal growth factor receptor amplification accompanied by mutations/drug resistance/prognosis分类
医药卫生引用本文复制引用
刘邦卿,李剑锋,刘晓辉,张劲男,胡亚丽..血清糖蛋白非转移性黑色素瘤蛋白B对表皮生长因子受体扩增伴随突变的非小细胞肺癌预后的预测作用[J].中国医科大学学报,2024,53(2):127-131,5.基金项目
河北省2024年度医学科学研究课题(20241213) （20241213）
