中国医科大学学报2024，Vol.53Issue(2)：160-165,6.DOI:10.12007/j.issn.0258-4646.2024.02.012
急性大血管闭塞性卒中患者中omentin-1、AQP4、VILIP-1与急诊血管内治疗后血管再通的关系
Relationship between omentin-1,AQP4,and VILIP-1 levels and vascular recanalization after emergency endovascular treatment in patients with acute large vessel occlusion stroke
摘要
Abstract
Objective To investigate the relationship between omentin-1,aquaporin 4(AQP4),and visinin-like protein 1(VILIP-1)levels and vascular recanalization after emergency endovascular treatment in patients with acute large vessel occlusion stroke(ALVOS)and their combined predictive efficacy.Methods In total,110 patients with ALVOS undergoing emergency endovascular treatment were categorized into a non-reopening group(23 patients)and a reopening group(87 patients)based on whether the blood vessels were re-opened after surgery.Clinical data and omentin-1,AQP4,and VILIP-1 levels were compared between the two groups.Factors influencing postoperative blood vessel reopening were analyzed,and nomograms were drawn to evaluate their predictive performance and calibration.Results Significant differences were observed in the proportion of patients with hypertension;preoperative NIHSS scores;emergency blood glucose;AQP4,VILIP-1,omentin-1,and platelet levels;time from onset to endovascular treatment;preoperative ASPECTS;and proportion of patients undergoing intravenous thrombolysis between the two groups(P＜0.05).Preoperative ASPECTS and omentin-1 levels were independent protective factors associated with postoperative vascular recanalization,whereas the time from onset to endovas-cular treatment,preoperative NIHSS scores,and AQP4 and VILIP-1 levels were independent risk factors associated with postoperative vascular recanalization(P＜0.05).The C-index of the nomogram for predicting postoperative vascular recanalization was 0.994,and the AUC of the nomogram for predicting postoperative vascular recanalization was 0.994,with a calibration degree of 0.975.Conclusion Omentin-1,AQP4,and VILIP-1 levels are important factors affecting vascular recanalization in patients with ALVOS after emergency endovascular treatment.Clinically,monitoring these levels may help to predict and evaluate early vascular recanalization fol-lowing treatment.关键词
急性大血管闭塞性卒中/血管内治疗/网膜素-1/水通道蛋白4/视锥蛋白样蛋白-1Key words
acute large vessel occlusion stroke/endovascular treatment/omentin-1/aquaporin 4/visinin-like protein 1分类
医药卫生引用本文复制引用
张海江,樊海梅,陈杰,任国勇,吴雪梅..急性大血管闭塞性卒中患者中omentin-1、AQP4、VILIP-1与急诊血管内治疗后血管再通的关系[J].中国医科大学学报,2024,53(2):160-165,6.基金项目
山西省应用基础研究计划(202103021224449) （202103021224449）
