中国药理学通报2024，Vol.40Issue(1)：1-5,5.DOI:10.12360/CPB202206011
靶向肺血管内皮功能障碍治疗肺动脉高压的研究进展
Research progress of targeted pulmonary vascular endothelial dysfunction in treatment of pulmonary hypertension
摘要
Abstract
Pulmonary hypertension(PH)is a progressive and fatal disease.The dysfunction of pulmonary artery endothelial cells(PAECs)is one of its important pathogenic factors.PAECs are monolayer flat epithelial cells,which play an impor-tant role in maintaining pulmonary vascular homeostasis.Studies have found that PAECs show damage and apoptosis at the early stage of PH development,while PAECs show anti-apoptotic characteristics at the late stage of PH development.The transi-tion of PAECs into mesenchymal cells induced by hypoxic and inflammatory factors is also involved in the pathogenesis of PH.Carcinoid metabolism and mitochondrial dysfunction,bone mor-phogenic type 2 receptor mutation,epigenetic changes and in-flammation of PAECs are the main pathogenesis of pulmonary vascular endothelial dysfunction in PH patients.New therapeutic measures targeting PAECs dysfunction are expected to play an important role in the treatment of PH in the future.关键词
肺动脉高压/内皮细胞/功能障碍/表型/发病机制/治疗Key words
pulmonary hypertension/endothelial cells/dys-function/phenotype pathogenesis/treatment引用本文复制引用
李娜,李占强,芦殿香..靶向肺血管内皮功能障碍治疗肺动脉高压的研究进展[J].中国药理学通报,2024,40(1):1-5,5.基金项目
国家自然科学基金资助项目(No 82374148,82060786,81860768) （No 82374148,82060786,81860768）
青海省科技厅自然科学基金面上资助项目(No 2021-ZJ-907) （No 2021-ZJ-907）
青海省昆仑英才·高端创新创业领军人才项目 （）
青海省昆仑英才·高端创新创业拔尖人才项目 （）
