靶向肺血管内皮功能障碍治疗肺动脉高压的研究进展OACSTPCD

Pulmonary hypertension(PH)is a progressive and fatal disease.The dysfunction of pulmonary artery endothelial cells(PAECs)is one of its important pathogenic factors.PAECs are monolayer flat epithelial cells,which play an impor-tant role in maintaining pulmonary vascular homeostasis.Studies have found that PAECs show damage and apoptosis at the early stage of PH development,while PAECs show anti-apoptotic characteristics at the late stage of PH development.The transi-tion of PAECs into mesenchymal cells induced by hypoxic and inflammatory factors is also involved in the pathogenesis of PH.Carcinoid metabolism and mitochondrial dysfunction,bone mor-phogenic type 2 receptor mutation,epigenetic changes and in-flammation of PAECs are the main pathogenesis of pulmonary vascular endothelial dysfunction in PH patients.New therapeutic measures targeting PAECs dysfunction are expected to play an important role in the treatment of PH in the future.