中国药理学通报2024，Vol.40Issue(1)：6-12,7.DOI:10.12360/CPB202209053
COPD细胞微环境体外模型建立的思路与方法
Ideas and methods of in vitro model establishment for cell microenvironment in COPD
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is major chronic disease threatening public health with complex pathological mechanisms.The change of the cell microenviron-ment of the lung is an important part of the pathophysiology of COPD.Cell culture technology is an important method to inves-tigate the pathological mechanism of COPD and evaluate the pharmacological effect of medicine.Here we introduce the com-position of the cell microenvironment of the lung,the change of the cell microenvironment in the pathological process of COPD,and summarize the application of in vitro model mimics cell mi-croenvironment of COPD in the study of mechanism.In addi-tion,we aim to put forward the ideas of the in vitro model estab-lishment of cell microenvironment of COPD.关键词
COPD/细胞微环境/体外模型/细胞共培养/气-液面培养/气血屏障/肺类器官Key words
COPD/cell microenvironment/in vitro model/cell co-culture/air-liquid interface culture,alveolar-capillary barri-er/lung organoids分类
基础医学引用本文复制引用
秦燕勤,刘含,李建生..COPD细胞微环境体外模型建立的思路与方法[J].中国药理学通报,2024,40(1):6-12,7.基金项目
国家自然科学基金资助项目(No 82104662) （No 82104662）
河南省重点研发与推广项目(科技攻关)(No 222102310141) （科技攻关）
河南省高等学校重点科研项目(No 22A360007) （No 22A360007）
河南省博士后科研项目(No 202101046) （No 202101046）
