COPD细胞微环境体外模型建立的思路与方法OACSTPCD

Chronic obstructive pulmonary disease(COPD)is major chronic disease threatening public health with complex pathological mechanisms.The change of the cell microenviron-ment of the lung is an important part of the pathophysiology of COPD.Cell culture technology is an important method to inves-tigate the pathological mechanism of COPD and evaluate the pharmacological effect of medicine.Here we introduce the com-position of the cell microenvironment of the lung,the change of the cell microenvironment in the pathological process of COPD,and summarize the application of in vitro model mimics cell mi-croenvironment of COPD in the study of mechanism.In addi-tion,we aim to put forward the ideas of the in vitro model estab-lishment of cell microenvironment of COPD.