中国药理学通报2024，Vol.40Issue(1)：12-15,4.DOI:10.12360/CPB202208029
小胶质细胞活化介导的神经元损伤与抑郁症的研究进展
Research progress of neuronal injury mediated by microglial activation and depression
摘要
Abstract
Depression is a common neurological disorder with high incidence,high recurrence and high disability,but its pathogenesis is unclear.In recent years,the protective and at-tacking effects of glial cells on neurons have become the frontier of neurological disease research.Neuronal injury caused by ab-normal activation of microglia(MG)plays an important role in the pathogenesis of depression.In this paper,through literature retrieval by GeenMedical and CNKI,the relevant pathways and key targets of MG activation in depression are summarized so as to provide a theoretical basis for further clinical research.关键词
小胶质细胞/神经元损伤/抑郁症/炎症/作用机制/免疫反应Key words
microglia/neuron damage/depression/inflamma-tion/mechanism of action/immune response分类
基础医学引用本文复制引用
何璎,邹蔓姝,韩远山,王宇红..小胶质细胞活化介导的神经元损伤与抑郁症的研究进展[J].中国药理学通报,2024,40(1):12-15,4.基金项目
国家自然科学青年基金项目(82104846) （82104846）
湖南中医药大学本科生科研创新基金项目(2023BKS152) （2023BKS152）
湖南省教育厅优秀青年项目(23B0360) （23B0360）
湖南省自然科学青年基金项目(2022JJ40323) （2022JJ40323）
长沙市自然科学基金项目(kq2202266) （kq2202266）
湖南省科药联合基金项目(2022JJ80092) （2022JJ80092）
