中国药理学通报2024，Vol.40Issue(1)：16-19,4.DOI:10.12360/CPB202306076
快速老化SAMP6小鼠骨代谢及其分子机制研究进展
Research progress on bone metabolism and molecular mechanisms in accelerated aging SAMP6 mice
摘要
Abstract
Senile osteoporosis(SOP)is a systemic bone disease characterized by increased susceptibility to fractures.The patho-genesis of SOP is complex and not well understood.Currently,the rapid aging model mouse,senescence accelerated mouse prone 6(SAMP6),is an ideal model for studying the mecha-nisms of SOP development and exploring its prevention and treat-ment.This model exhibits characteristics including increased bone fragility,degradation of bone microstructure,loss of bone matrix,and abnormal metabolism and dysfunction of bone cells,faithfully replicating the process of SOP occurrence and progres-sion at both macroscopic and microscopic levels.关键词
老年性骨质疏松/动物模型/快速老化小鼠P6品系/骨代谢/Wnt/β-catenin信号通路/功能分子Key words
senile osteoporosis/animal models/senescence ac-celerated mouse prone 6/bone metabolism/Wnt/β-catenin sig-naling pathway/functional molecules分类
医药卫生引用本文复制引用
马绍勇,杨梦,王佳佳,杨亚军..快速老化SAMP6小鼠骨代谢及其分子机制研究进展[J].中国药理学通报,2024,40(1):16-19,4.基金项目
国家自然科学基金资助项目(No 82274614) （No 82274614）
