中国药理学通报2024，Vol.40Issue(1)：20-25,6.DOI:10.12360/CPB202208113
靶向血小板的抗肿瘤药物研究进展
Research progress of antineoplastic drugs targeting platelets
摘要
Abstract
Platelets have long been recognized as key players in hemostasis and thrombosis;however,there is growing evidence that they are also involved in cancer.Preclinical and clinical studies have shown that platelets can promote tumorigenesis and metastasis through various crosstalks between platelets and canc-er cells.Platelets play an active role in all stages of tumorigene-sis,including tumor growth,tumor cell extravasation,and me-tastasis.In addition,thrombocytosis in cancer patients is associ-ated with poor patient survival.Platelets are also well-placed to coordinate local and distant tumor-host interactions due to the a-bundance of microparticles and exosomes.Therefore,antitumor drugs targeting platelets have great development and application prospects.The following will review the research progress of an-ti-tumor drugs targeting platelets.关键词
血小板活化/血小板受体/肿瘤/血小板肿瘤细胞相互作用/抗肿瘤药/肿瘤发生和转移Key words
platelet activation/platelet receptor/tumor/plate-let-tumor cell interaction/antitumor drugs/tumorigenesis and metastasis分类
基础医学引用本文复制引用
周玥珂,钱程,唐彧,韦忠红,陆茵,王爱云..靶向血小板的抗肿瘤药物研究进展[J].中国药理学通报,2024,40(1):20-25,6.基金项目
国家自然科学基金资助项目(No 81573859) （No 81573859）
全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号文) （国中医药人教函[2019]128号文）
江苏省研究生科研创新计划(SJCX22_0791) （SJCX22_0791）
