中国药理学通报2024，Vol.40Issue(1)：25-30,6.DOI:10.12360/CPB202209104
细胞焦亡与肺动脉高压的关系及治疗肺动脉高压药物研究进展
Advances in relationship between pyroptosis and pulmonary arterial hypertension and therapeutic drugs
摘要
Abstract
Pyroptosis is the programmed death of cells accompa-nied by an inflammatory response and is widely involved in the development of a variety of diseases,such as infectious diseases,cardiovascular diseases,and neurodegeneration.It has been shown that cellular scorching is involved in the pathogenesis of pulmonary arterial hypertension(PAH)in cardiovascular disea-ses.Patients with PAH have perivascular inflammatory infiltrates in lungs,pulmonary vasculopathy exists in an extremely inflam-matory microenvironment,and pro-inflammatory factors in cellu-lar scorching drive pulmonary vascular remodelling in PAH pa-tients.This article reviews the role of cellular scorch in the path-ogenesis of PAH and the related research on drugs for the treat-ment of PAH,with the aim of providing new ideas for clinical treatment of PAH.关键词
细胞焦亡/动脉性肺动脉高压/肺动脉高压/治疗药物/炎症小体/发病机制Key words
pyroptosis/pulmonary arterial hypertension/pulmo-nary hypertension/therapeutic drugs/inflammasome/pathogen-esis分类
基础医学引用本文复制引用
颜倩,艾启迪,陈乃宏,孙洋,龙俊鹏,刘莎莎,姚娇,林玉婷,阳松威,杨岩涛,裴刚..细胞焦亡与肺动脉高压的关系及治疗肺动脉高压药物研究进展[J].中国药理学通报,2024,40(1):25-30,6.基金项目
国家自然科学基金资助项目(No 82174271) （No 82174271）
湖南省自然科学基金项目(No 2021JJ30512,2022JJ40456,2022JJ40313) （No 2021JJ30512,2022JJ40456,2022JJ40313）
湖南省科技厅优秀青年项目(No 21B0354) （No 21B0354）
长沙市自然科学基金(No kq2202269,kq2014091) （No kq2202269,kq2014091）
湖南中医药大学生物工程重点学科([2018]No 3) （[2018]No 3）
湖南中医药大学中药学一流学科建设项目 （）
