摘要
Abstract
Objective:To analyze the influential factors of drug compliance of subjects in clinical trials of oral antineoplastic drugs.Methods:Questionnaires were used to collect the information of the subjects.Rank sum test was used for single factor analy-sis and multiple linear regression was used for multi-factor analysis.Results:323 participants were included with a median MMAS-8 score of 8(6,8).The results of univariate analysis showed that permanent address,degree of disease,whether the oral antineoplas-tic drugs is on the market,way to follow-up,whether participated in clinical trials in the past,adverse reactions during medication and pharmaceutical intervention had statistically significant effects on MMAS-8 score in this study(P＜0.05).The results of multi-factor analysis showed that:Pharmaceutical intervention(β=-0.198,P＜0.001),permanent residence in Guangzhou(β=-0.197,P＜0.001),oral antineoplastic drugs are on the market(p=-0.431,P＜0.001),hospitalized subjects(p=-0.203,Patients who had participated in clinical trials(β=-0.155,P=0.001)had higher drug compliance;Patients with adverse reactions during medication(β=0.101,P=0.028)had lower compliance.Conclusion:Subjects'drug compliance is related to whether the oral antineoplastic drugs is on the market,way to follow-up,pharmaceutical intervention,permanent address,whether participated in clinical trials in the past,and adverse reactions during medication.Clinical trials of antineoplastic drugs can improve subjects'drug compliance and promote the smooth development of clinical trials by taking appropriate intervention measures.关键词
口服抗肿瘤药/临床试验用药品/用药依从性/影响因素/药学干预Key words
Oral antineoplastic drugs/Clinical trial drugs/Drug compliance/Influential factors/Pharmacy interventions分类
医药卫生
