中国药物评价2023，Vol.40Issue(6)：525-529,5.
雷珠单抗与康柏西普治疗白内障术后黄斑水肿的临床效果观察
Clinical Effect of Leizumab and Compaximab in the Treatment of Macular Edema after Cataract Operation
摘要
Abstract
Objective:To observe and compare the clinical efficacy and safety of Leizumab and Comcaercep in the treatment of Pseud-ophakic cystoid macular edema(PCEM)after cataract surgery.Methods:Eighty-nine patients with PCEM admitted to our hospital from May 2021 to March 2023 were selected and divided into control group and observation group according to the treatment plan.The control group(44 cases)was treated with Compaplomp,and the observation group(45 cases)was treated with leizumab.The clinical efficacy,corneal nerve fiber density and length,visual acuity(BCVA),intraocular pressure,macular thickness(CMT),aqueous humor factors[interleukin-6(IL-6),IL-37,vascular endothelial growth factor(VEGF)]and postoperative adverse reactions were compared between the two groups.Results:The total treatment efficiency of observation group was 88.89％compared with control group 93.18％,there was no significant difference(P＞0.05).After 1,2 and 3 injections,BCVA,IOP and CMT before injection were significantly improved(P＜0.05),but there were no significant differences in BCVA,IOP and CMT between the two groups(P＞0.05).There was no signifi-cant difference in CNFD between the two groups after 1 infusion,2 infusion and 3 infusion(P＞0.05),there was no significant difference in CNFL between the observation group and before infusion(P＞0.05),and CNFL was significantly decreased between the control group and before infusion and observation group(P＜0.05).After 3 times of injection,IL-6,IL-37 and VEGF were decreased in 2 groups compared with before treatment(P＜0.05),and there were no significant differences in IL-6,IL-37 and VEGF between 2 groups(P＞0.05).The incidence of adverse reactions in the observation group was 6.67％compared with 4.55％in the control group(P＞0.05).Conclusion:The efficacy and safety of lezumab in the treatment of PCEM are comparable to that of Compaucept,but the former has a certain effect on corneal nerves.关键词
白内障/黄斑水肿/雷珠单抗/康柏西普/角膜神经Key words
Cataract/Macular edema/Leizumab/Compacept/Corneal nerve分类
医药卫生引用本文复制引用
陈海波,许超,李娟..雷珠单抗与康柏西普治疗白内障术后黄斑水肿的临床效果观察[J].中国药物评价,2023,40(6):525-529,5.基金项目
河南省医学科技攻关计划联合共建项目LHGJ20220928 （）
