中国药物评价2023，Vol.40Issue(6)：530-536,7.
SGLT-2抑制剂引起2型糖尿病患者上呼吸道感染的网状Meta分析
Network Meta Analysis of Upper Respiratory Tract Infection in Type 2 Diabetes Patients Induced by SGLT-2 Inhibitors
摘要
Abstract
Objective:To systematically evaluate the correlation between the risk of upper respiratory tract infection caused by different SGLT-2(sodium glucose cotransporter-2)inhibitors in patients with type 2 diabetes by using a mesh meta-analysis method.Methods:The relevant Chinese and English databases were searched to obtain the randomized controlled trials of different SGLT-2 inhibitors in the treat-ment of type 2 diabetes patients.The search time was from the establishment of the database to February 2023.According to the inclusion and exclusion criteria,literature was screened,data was extracted,and methodological quality evaluation was conducted on the included studies.A mesh meta-analysis was conducted using Stata 15.1 software.Results:12 articles were ultimately included,with a total of 5615 patients.The results of the mesh meta-analysis showed that compared with Engliflozin 10 mg(RR=1.74,95％CI=1.05,5.75)and placebo(RR=1.10,95％CI=1.06,4.83),Cargliflozin 300mg had an increased risk of upper respiratory tract infection.There was no statistically significant difference between other different doses of SGLT-2 inhibitors;The sorting result of network meta-analysis showed that it was not easy to cause upper respiratory tract infection events when SGLT-2 inhibitors were used to treat type 2 diabetes.The sorting result was cagelin 50 mg＞enggligin 10 mg＞daggligin 1 mg＞eggligin 1 mg＞eggligin 5 mg＞daggligin 2.5 mg＞daggligin 5 mg＞caggli-gin 100 mg＞eggligin 10 mg＞eggligin 25 mg＞placebo＞enggligin 25 mg＞daggligin 10 mg＞caggligin 200 mg＞caggligin 300 mg.Conclusion:When SGLT-2 inhibitor is used to treat type 2 diabetes,the incidence of respiratory infection is the lowest when 50 mg of ka-gliflozin is used,and the highest when 300 mg of kagliflozin is used.关键词
钠-葡萄糖共转运蛋白-2抑制剂/上呼吸道感染/2型糖尿病/网状Meta分析Key words
Sodium glucose co transporter-2 inhibitor/Upper respiratory tract infection/Type 2 diabetes/Mesh Meta analysis分类
医药卫生引用本文复制引用
令娟,谢卓霖,王燕,张定华,马冬梅,罗向霞..SGLT-2抑制剂引起2型糖尿病患者上呼吸道感染的网状Meta分析[J].中国药物评价,2023,40(6):530-536,7.基金项目
甘肃省卫生健康行业科研计划项目(GSWSKY2022-44) （GSWSKY2022-44）
甘肃省名中医张定华传承工作室建设项目,"甘卫中医函[2022]50号" （）
国家中医优势专科建设项目(甘卫函[2023]63号) （甘卫函[2023]63号）
甘肃省人民医院院内科研基金项目资助(23GSSYF-9) （23GSSYF-9）
