中国医学创新2024，Vol.21Issue(1)：27-30,4.DOI:10.3969/j.issn.1674-4985.2024.01.007
超声引导前锯肌平面阻滞复合全麻对乳腺癌改良根治术患者围手术期免疫功能的影响
Effect of Ultrasound Guided Serratus Anterior Plane Block Combined with General Anesthesia on Perioperative Immune Function in Modified Radical Mastectomy for Breast Cancer Patients
摘要
Abstract
Objective:To investigate the effect of ultrasound guided serratus anterior plane block(SAPB)combined with general anesthesia on immune function in the perioperative period of modified radical mastectomy for breast cancer patients.Method:A total of eighty patients with breast cancer undergoing modified radical mastectomy(MRM)from April 2020 to July 2022 in Nanchang Third Hospital were selected,were randomly divided into control group(n=40)and experimental group(n=40).The control group was operated under simple general anesthesia,and the experimental group was operated under ultrasound guided SAPB combined general anesthesia;at 30 min before anesthesia(T0),intraoperative(T1),and at the end of operation(T2),the inflammatory indicators[interleukin(IL)-6,IL-8,and tumor necrosis factor-α(TNF-α)],serum cortisol(Cor)of the two groups were compared;the immune function(T lymphocyte subsets)of the two groups were compared before and 24 h after operation;at 6,12,24 and 48 h after operation,the pain sensation[visual analogue scale(VAS)]of the two groups was compared.Result:At T1 and T2,the levels of inflammation and stress indicators in the two groups were gradually increased compared with those at T0,and IL-6,IL-8,TNF-α and Cor in the experimental group at various time points were lower than those in the control group(P＜0.05).At 24 h after operation,CD4+ decreased significantly and CD8+ increased significantly in the two groups compared to those preoperative,but CD4+ in the experimental group was higher than that in the control group,and CD8+ was lower than that in the control group(P＜0.05).At 6,12,24,48 h after operation,the VAS scores of the two groups decreased gradually,and those in the experimental group were lower than those in the control group(P＜0.05).Conclusion:The application of ultrasound guided SAPB combined with general anesthesia in MRM patients can alleviate stress and inflammatory reactions,alleviate pain levels,and have a certain degree of immune protection.关键词
乳腺癌改良根治术/全麻/前锯肌平面阻滞/免疫功能Key words
Modified radical mastectomy for breast cancer/General anesthesia/Serratus anterior plane block/Immune function引用本文复制引用
徐勇民,傅艳师,王广珊,彭娟,赵慧磊..超声引导前锯肌平面阻滞复合全麻对乳腺癌改良根治术患者围手术期免疫功能的影响[J].中国医学创新,2024,21(1):27-30,4.基金项目
江西省卫生健康委科技计划项目(20202013) （20202013）
