摘要
Abstract
Objective:To explore the clinical effect and safety of Rivaroxaban in the treatment of elderly patients with non-valvular atrial fibrillation complicate with cardiac insufficiency.Method:A total of 86 elderly patients with non-valvular atrial fibrillation complicated with cardiac insufficiency who received treatment in First People's Hospital of Fuzhou from July 2021 to June 2022 were selected and divided into the control group and the observation group,with 43 cases in each group.The control group was treated with Warfarin Sodium Tablets,and the observation group was treated with Rivaroxaban Tablets.Both groups were treated for 3 months.The clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),N-terminal pro-B-type natriuretic peptide(NT-proBNP)],coagulation function[activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT)]levels,embolism and bleeding incidence were compared between the two groups.Result:After treatment,the total effective rate of the observation group was 93.02%,which was higher than 76.74%of the control group,the difference was statistically significant(P＜0.05).After treatment,the NT-proBNP in the observation group was lower than that in the control group,the LVEF in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).After treatment,APTT,TT and PT in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The incidence of embolism and bleeding in the observation group was 2.33%,which was significantly lower than 23.26%in the control group,the difference was statistically significant(P＜0.05).Conclusion:Rivaroxaban in the treatment of elderly patients with non-valvular atrial fibrillation complicate with cardiac insufficiency can obtain relatively ideal clinical effect,which is helpful to improve the cardiac function and coagulation function of patients,reduce the incidence of embolism and bleeding,and has high safety.关键词
非瓣膜性心房颤动合并心功能不全/高龄患者/利伐沙班/华法林/心功能不全/凝血功能Key words
Non-valvular atrial fibrillation complicate with cardiac insufficiency/Elderly patients/Rivaroxaban/Warfarin/Cardiac insufficiency/Coagulation function
