中国医学创新2024，Vol.21Issue(1)：149-154,6.DOI:10.3969/j.issn.1674-4985.2024.01.036
部分泛素特异性蛋白酶生物学功能的研究进展
Research Progress in Biological Functions of Partial Ubiquitin-specific Proteases
摘要
Abstract
The family of ubiquitin-specific proteases(USPs)is the most abundant member of the deubiquitinating enzyme family,different and is mainly present in skeletal muscle,heart,liver,brain,pancreas and other tissues,with differential expression among different species.Current studies have shown that the USPs has a great role in organismal life processes,although the mechanism by which the USPs specifically selects ubiquitin chains for hydrolysis is not clear.USPs have important clinical significances in the regulation of tumorigenesis and metastasis,immune regulation,inflammatory response,energy metabolism and viral infection.In this paper,we review reserch progress on biological functions of partial USPs in recent years,expecting to provide new ideas for the diagnosis and treatment of related diseases.关键词
泛素特异性蛋白酶/肿瘤/治疗靶点Key words
Ubiquitin-specific proteases/Tumors/Therapeutic target引用本文复制引用
杨静,张丽璇,张晨钰,安康..部分泛素特异性蛋白酶生物学功能的研究进展[J].中国医学创新,2024,21(1):149-154,6.基金项目
河北省自然科学基金(C2018405046) （C2018405046）
河北北方学院省属高校基本科研项目(JYT2020021) （JYT2020021）
河北北方学院大学生创新创业训练计划项目(xj202151) （xj202151）
