中国医学工程2023，Vol.31Issue(12)：66-70,5.DOI:10.19338/j.issn.1672-2019.2023.12.013
LISA技术与气管插管内PS治疗NRDS对早产儿神经系统影响的临床研究
Effects of LISA technology and endotracheal intubation with PS therapy on nervous system of premature infants with NRDS
摘要
Abstract
[Objective]To analyze the effects of less invasive surfactant application(LISA)technology and tracheal intubation of pulmonary surfactant(PS)in the treatment of neonatal respiratory distress syndrome(NRDS)on the nervous system of premature infants.[Methods]Eighty premature infants admitted to the neonatal intensive care unit(NICU)at Kaifeng Children's Hospital from September 2021 to December 2022 were selected as the study subjects.They were randomly divided into two groups using a random number table method,with 40 cases in each group.The control group received endotracheal intubation PS treatment,while the observation group received LISA PS treatment.The results of two-dimensional cranial ultrasound examination,levels of cerebral hemodynamic indicators,fractional anisotropy(FA)values of cranial MRI examination,and abnormal rates of neurological development evaluation indicators were compared between the two groups.[Results]After treatment,the transverse diameter and frontal lobe thickness of the brain in the observation group were higher than those in the control group,the incidence of paraventricular white matter echo enhancement was lower than that in the control group,the levels of peak systolic velocity(PSV),end diastolic velocity(EDV),mean flow velocity(MFV)in the observation group were higher than those in the control group,and the levels of resistance index(RI)and pulsatility index(PI)were lower than those in the control group.After treatment,the FA levels of splenium of corpus callosum,genu of corpus callosum,posterior limb of internal capsule,thalamus,caudate nucleus and occipital lobe were higher than those of the control group,and the abnormal rate of amplitude integrated electroencephalogram(aEEG)corrected for 40 weeks of gestation in the observation group was lower than that in the control group,the difference was significant(P＜0.05).[Conclusion]LISA technology PS treatment can improve cerebral blood flow velocity,improve microstructure changes of brain nerve tissue,prevent and treat brain injury,and protect neural function compared with tracheal intubation PS treatment.关键词
呼吸窘迫综合征/早产儿/微创表面活性物质/气管插管肺表面活性物质/神经系统Key words
respiratory distress syndrome/premature infants/minimally invasive surfactant/tracheal intubation pulmonary surfactant/nervous system分类
医药卫生引用本文复制引用
杨晓宇,王雪芹,王卫国,杨培源,唐军..LISA技术与气管插管内PS治疗NRDS对早产儿神经系统影响的临床研究[J].中国医学工程,2023,31(12):66-70,5.基金项目
开封市科技计划发展项目(2203107) （2203107）
