中国医学工程2023，Vol.31Issue(12)：71-75,5.DOI:10.19338/j.issn.1672-2019.2023.12.014
神经松动术配合夹脊电针对糖尿病周围神经病变患者平衡功能的影响及安全性分析
Effect and safety analysis of nerve loosening surgery combined with spinal clip electroacupuncture on balance function in DPN patients
摘要
Abstract
[Objective]To observe the effect of nerve loosening surgery combined with spinal electroacupuncture onbalance function and treatment safety in diabetes peripheral neuropathy(DPN)patients.[Methods]This is a prospective cohort study.The cases were included from January 2020 to January 2023.The study subjects were 110 patients with DPN.The enrolled patients were randomly divided into two groups by computer,namely,the electroacupuncture group(55 cases)and the combined group(55 cases).The electroacupuncture group was treated with conventional Jiaji electroacupuncture,and the combined group was treated with nerve mobilization combined with Jiaji electroacupuncture.The neurological electrophysiology indicators,neurotrophic factors,and improvement of balance function before and after treatment,incidence of related complications after treatment,and treatment safety were compared between the two groups.[Results]Before treatment,there was no statistical difference in the neurological electrophysiology indexes,neurotrophic factors and balance function between the two groups(P＞0.05).After treatment,the motor conduction velocity(MCV)of the median nerve in the combined group was 50.33±10.25 m/s,the sensory conduction velocity(SCV)was 52.33±10.41 m/s,the MCV of the common peroneal nerve was 53.11±10.46 m/s,and the SCV was 52.47±10.28 m/s;compared with the electroacupuncture group(44.16±10.27 m/s,46.24±10.15 m/s,47.25±10.62 m/s,and 45.11±10.36 m/s),the above indicators were higher(P＜0.05).After treatment,the brain-derived neurotrophic factor(BDNF)of the combination group was 11.45± 3.27 μg/L,nerve growth factor(NGF)was 44.29±10.37 pg/mL,neurotrophins-3(NT-3)was 172.44±20.76 pg/mL;compare with the electroacupuncture group(9.44±2.28 μg/L,38.45±10.16 pg/mL,and 158.44±20.18 pg/mL),above indicators were all higher(P＜0.05).Under different treatment regimens,the Berg Balance Scale(BBS)score of the combination group after 1 day of treatment was 35.33±5.25 points,the BBS score after 7 days of treatment was 42.77±10.32 points,and the BBS score after 14 days of treatment was 49.15±10.36 points;compared with the electroacupuncture group(32.41±5.16 points,36.15±10.41 points,and 42.26± 10.35 points),the above BBS score was higher(P＜0.05).After treatment,the incidence of DPN related complications in the combination group was 7.27％(4/55),which was lower compared with the electroacupuncture group[18.18％(10/55)](P＜0.05).No adverse reactions occurred in both groups.[Conclusion]Nerve mobilization combined with Jiaji electroacupuncture treatment of DPN can effectively improve the patients'nerve electrophysiological activity and up regulate the expression of neurotrophin,which has positive significance in promoting the recovery of patients'balance function and reducing the risk of DPN related complications,with high safety.关键词
糖尿病周围神经病变/神经松动术/夹脊电针/平衡功能/神经电生理活动Key words
diabetes peripheral neuropathy/neurolysis/Jiaji electroacupuncture/balance function/neuroelectrophysiological activity分类
医药卫生引用本文复制引用
张占军,王红晓..神经松动术配合夹脊电针对糖尿病周围神经病变患者平衡功能的影响及安全性分析[J].中国医学工程,2023,31(12):71-75,5.基金项目
河南省医学科技攻关项目(LHGJ202102412) （LHGJ202102412）
