中国医学前沿杂志（电子版）2023，Vol.15Issue(12)：34-41,8.DOI:10.12037/YXQY.2023.12-06
急性果糖过量摄入对健康成人血浆胰岛素及脂肪因子水平的影响
Effect of acute fructose overdose on plasma insulin and adipokine levels in healthy adults
摘要
Abstract
Objective To observe the effects of acute fructose overdose on blood levels of insulin,leptin,adiponectin,and progranulin(PGRN)in healthy adults.Methods Sixteen healthy adults were included in an self-controlled case series study from Hebei General Hospital in May 2023 and were given 75g of fructose solution and 75g of glucose solution respectively,with a 1-week washout period between interventions.Blood glucose,insulin,C-peptide,leptin,adiponectin,PGRN,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),osteocalcin,leukocyte 6(IL-6),and C-reactive protein(CRP)were measured in the overnight fasting period and at 0.5,1.0,2.0,and 3.0h after fructose and glucose administration.Results Blood glucose,insulin and C-peptide levels increased to different degrees after acute fructose and glucose loading(P<0.05),and increased most significantly at 30min.The degree of insulin elevation was much greater after acute glucose loading than after acute fructose loading,and the 3-hour blood glucose,insulin,and C-peptide area under the curve(AUC)after acute glucose loading were all were significantly higher after acute fructose loading(P<0.01).There were no significant changes in the levels of leptin,adiponectin,PGRN,TC,TG,HDL-C,LDL-C,osteocalcin,IL-6,and CRP after acute fructose and glucose loading compared with those at 0 min(P>0.05).And there was no statistically significant difference in the 3h AUC of leptin,adiponectin,PGRN,TC,TG,HDL-C,LDL-C,osteocalcin,IL-6,and CRP between the two interventions(P>0.05).Conclusions Acute fructose overdose results in elevated blood glucose and insulin levels in healthy adults,but has no significant effect on leptin,adiponectin,or PGRN levels.关键词
果糖/胰岛素/瘦素/脂联素/颗粒蛋白前体Key words
Fructose/Insulin/Leptin/Adiponectin/Progranulin引用本文复制引用
李欢,侯艺林,王晴,宋光耀,任路平..急性果糖过量摄入对健康成人血浆胰岛素及脂肪因子水平的影响[J].中国医学前沿杂志（电子版）,2023,15(12):34-41,8.基金项目
Scientific Research Fund of Hebei Province(H2022307033) 河北省自然科学基金(H2022307033) （H2022307033）
