中国医学装备2024，Vol.21Issue(1)：9-14,20,7.DOI:10.3969/j.issn.1672-8270.2024.01.002
闪光放射治疗(Flash-RT)在肿瘤治疗中的研究进展
Research advance of Flash-RT in tumor treatment
摘要
Abstract
The Flash radiotherapy(Flash-RT),which is the key breakthrough in the basic field of radiotherapy technique,which is expected to cause a new major transformation in the field of radiotherapy.In this paper,we reviewed the latest research advances of the application and the mechanism exploration of Flash-RT in tumor treatment.Current studies have found that both the Flash-RT with electron beams and photon and the Flash-RT with proton can reduce injury of normal tissue than radiotherapy with conventional dose-rate,but the relevant mechanisms are not yet clearly understood,which includes but not limited to oxygen depletion,DNA damage,cellular senescence,apoptosis and immune response.The difference of Flash-RT injury between tumor tissue and normal tissue further reduces the limitations of radiotherapy,and reduces the adverse reaction and complication compared with conventional radiotherapy,which has wide application prospects.关键词
闪光放射治疗(Flash-RT)/超高剂量率/肿瘤治疗/机制Key words
Flash radiotherapy(Flash-RT)/Ultra-high dose rate/Tumor treatment/Mechanism分类
医药卫生引用本文复制引用
王源,杜乐辉,张沛,商庆超,郭兴东,卢江岳,雷霄,曲宝林..闪光放射治疗(Flash-RT)在肿瘤治疗中的研究进展[J].中国医学装备,2024,21(1):9-14,20,7.基金项目
科研课题(ALB23J008) Research project(ALB23J008) （ALB23J008）
