中国医学装备2024，Vol.21Issue(1)：46-50,54,6.DOI:10.3969/j.issn.1672-8270.2024.01.009
酰胺质子转移MRI技术在预测急性缺血性脑卒中预后情况的可行性研究
Study on the feasibility of MRI technique with APT in predicting the prognosis of acute ischemic stroke
赵傲 1武新英 1付彤 1王培炎 1蒋腾 2林海 3于慧华 1袁健闵 3刘林栋1
作者信息
- 1. 南京医科大学附属南京医院(南京市第一医院)医学影像科 南京 210006
- 2. 南京医科大学附属南京医院(南京市第一医院)神经内科 南京 210006
- 3. 上海联影中央研究院 上海 201800
- 折叠
摘要
Abstract
Objective:To study the feasibility of magnetic resonance imaging(MRI)technique with amide proton transfer(APT)in predicting the prognosis of cerebral stroke.Methods:A total of 71 patients with acute cerebral stroke who admitted to the Nanjing First Hospital,Nanjing Medical University from September 2022 to May 2023 were selected.All of them underwent the test of National Institute of Health Stroke Scale(NIHSS),and received the MRI examination with chemical exchange saturation transfer(CEST).According to the modified Rankin scale(mRS)values of 1-month follow-up,they were divided into favorable recovery group(mRS<2,44 cases)and poor group(mRS≥2,27 cases).The asymmetric magnetization transfer ratio(MTRasym)image(APT)was obtained by analyzing data with special software.And then,the difference(△APTw)of APT values between ischemic zone and contralateral normal tissue was further calculated.The △APTw values of two groups were compared and analyzed,and the Pearson correlation analysis was adopted to analyze the correlation among △APTw,NIHSS and mRS.The receiver operating characteristics(ROC)curve was drawn,and the area under curve(AUC)of ROC curve was calculated.Results:There were significant positive correlations among △APTw,NIHSS and mRS scores(R2=0.659,0.522,P<0.001),and the differences of △APTW,NIHSS and mRS scores between the favorable recovery group and poor group were significant(t=5.73,6.36,13.92,P<0.05),respectively.The AUC value was 0.886,and the sensitivity and specificity of prediction were respectively 77.8%and 95.5%.The positive and negative predictive values were respectively 91.3%and 87.5%.Conclusion:APT imaging technique has feasibility in predicting the prognosis of acute cerebral ischemic stroke.关键词
化学交换饱和度转移(CEST)/酰胺质子转移(APT)/磁共振成像(MRI)/脑卒中/曲线下面积(AUC)/敏感度/特异度Key words
Chemical exchange saturation transfer(CEST)/Amide proton transfer(APT)/Magnetic resonance imaging(MRI)/Stroke/Area under curve(AUC)/Sensitivity/Specificity分类
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赵傲,武新英,付彤,王培炎,蒋腾,林海,于慧华,袁健闵,刘林栋..酰胺质子转移MRI技术在预测急性缺血性脑卒中预后情况的可行性研究[J].中国医学装备,2024,21(1):46-50,54,6.
