中国药业2024，Vol.33Issue(2)：32-36,5.DOI:10.3969/j.issn.1006-4931.2024.02.008
抗菌药物静脉给药对血浆氧化三甲胺水平的影响
Effect of Intravenous Administration of Antibiotics on the Level of Plasma Trimethylamine N-Oxide
摘要
Abstract
Objective To investigate the effect of intravenous administration of antibiotics on the level of plasma trimethylamine N-oxide(TMAO).Methods A total of 228 patients(130 males and 98 females)with infectious diseases receiving intravenous administration of antibiotics more than 7 d in the Affiliated Hospital of Xiangnan University from October 2020 to August 2021 were selected.Ultra-high-performance liquid chromatography-tandem mass spectrometry was used to detect the plasma TMAO level in patients before and after antibiotic treatment.The effects of gender,age,antibiotic types,duration of medication,cardiovascular disease(CVD)on the TMAO level were analyzed,as well as the correlation of infectious indicators[C-reactive protein(CRP),white blood cell count(WBC),neutrophil percentage(NEUT%),erythrocyte sedimentation rate(ESR),procalcitonin(PCT)]with TMAO level.Results Compared with that before the use of antibiotics,the plasma TMAO level of patients significantly decreased after 7 d of use(P<0.01);the plasma TMAO level significantly decreased after single use of β-lactams(P<0.01),while that was similar after single use of quinolones(P>0.05).The TMAO level of male patients was similar with that of female patients(P>0.05),but showed an overall increasing trend with the age.Compared with that after use of antibiotics for 1-7 d and 8-14 d,the plasma TMAO level in patients significantly decreased after use for 15-21 d(P<0.01).There was no significant difference in plasma TMAO level between patients treated with antibiotics combined with probiotics and antibiotics alone(P>0.05).The plasma TMAO level in patients with infectious diseases and CVD was significantly higher than that in patients with infectious diseases alone(P<0.01).There was no significant correlation of various infectious indicators with TMAO level(P>0.05).Conclusion Intravenous administration of antibiotics can significantly decrease the plasma TMAO level in patients with infectious diseases,and the decrease degree may be related to the duration of medication and whether infectious diseases complicated with CVD.关键词
氧化三甲胺/抗菌药物/静脉给药/血药浓度/用药时长/心血管疾病Key words
trimethylamine N-oxide/antibiotics/intravenous administration/plasma concentration/duration of medication/cardiovascular disease分类
医药卫生引用本文复制引用
王时云,陈露露,方青,李超,欧阳冬生,李晓晖,舒海媚,罗春阳..抗菌药物静脉给药对血浆氧化三甲胺水平的影响[J].中国药业,2024,33(2):32-36,5.基金项目
湖南省自然科学基金[2022JJ80100] （）
湖南省科技创新计划项目[2018SK52008,2017TP1037] （）
湖南省卫生健康委科研计划项目[B202313018451]. （）
