中国药业2024，Vol.33Issue(2)：94-97,4.DOI:10.3969/j.issn.1006-4931.2024.02.023
司美格鲁肽联合常规方案治疗2型糖尿病并颈动脉粥样硬化临床研究
Clinical Study of Semaglutide Combined with Conventional Regimen in the Treatment of Diabetes Mellitus Type 2 Complicated with Carotid Atherosclerosis
摘要
Abstract
Objective To investigate the clinical efficacy of semaglutide combined with conventional regimen in the treatment of diabetes mellitus type 2(T2DM)complicated with carotid atherosclerosis.Methods A total of 68 patients with T2DM and carotid atherosclerosis admitted to hospital from October 2021 to August 2022 were selected and randomly divided into the control group and the observation group,with 34 cases in each group.The patients in the two groups were given a conventional treatment regimen(oral hypoglycemic drugs,Atorvastatin Calcium Tablets),on this basis,the patients in the observation group were given the subcutaneous injection of Semaglutide Injection.Both groups were treated continuously for six months.Results After treatment,the body mass,body mass index(BMI),blood glucose indexes[fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1c)]levels,blood lipid indexes[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]levels,carotid intima-media thickness(IMT)and maximum plaque-sectional area(Smax)in the observation group were significantly better(P<0.05),the LDL-C,HDL-C levels and Smax were similar to those in the control group(P>0.05),while the others were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(14.71%vs.20.59%,P>0.05).Conclusion Semaglutide combined with conventional regimen in the treatment of T2DM complicated with carotid atherosclerosis can effectively control the patients'body mass,BMI,blood glucose and blood lipid levels,and improve the carotid plaques.关键词
司美格鲁肽/2型糖尿病/颈动脉粥样硬化/血糖/血脂/体质量/颈动脉斑块Key words
semaglutide/diabetes mellitus type 2/carotid atherosclerosis/blood glucose/blood lipid/body mass/carotid plaque分类
医药卫生引用本文复制引用
邓文珍,易吉秀,陈诚,钟媛,陈丽娟,李凌..司美格鲁肽联合常规方案治疗2型糖尿病并颈动脉粥样硬化临床研究[J].中国药业,2024,33(2):94-97,4.基金项目
重庆市黔江区科技计划项目[黔科计2022042]. （）
