中国药业2024，Vol.33Issue(2)：110-113,4.DOI:10.3969/j.issn.1006-4931.2024.02.027
仿制与原研注射用头孢呋辛钠治疗儿童支气管肺炎疗效、安全性及经济性比较
Comparison of Efficacy,Safety and Economy Between Generic and Original-Patented Cefuroxime Sodium for Injection in the Treatment of Pediatric Bronchopneumonia
摘要
Abstract
Objective To compare the efficacy,safety and economy of generic and original-patented Cefuroxime Sodium for Injection in the treatment of pediatric bronchopneumonia.Methods Basic information and clinical data of children with bronchopneumonia treated with Cefuroxime Sodium for Injection at the Second People's Hospital of Hefei from January 2019 to December 2022 were extracted from the hospital information system archive database.The above children were divided into the generic group and the original-patented group according to different drugs.The efficacy was evaluated based on clinical effective rate and cases of bacterial clearance.The safety was evaluated based on the incidence of adverse reactions.The cefuroxime sodium fees was taken as the drug costs to calculate the costs and cost-effectiveness ratio.Results After matching at a ratio of 1∶2 by the propensity score matching,104 cases and 208 cases were included in the generic group and the original-patented group respectively.There was no significant difference in the clinical effective rate,cases of bacterial clearance and incidence of adverse reactions between the two groups(P>0.05).The cost-effectiveness ratio in the generic group was 2.26,which was significantly lower than 11.41 in the original-patented group.Conclusion The efficacy and safety of generic and original-patented Cefuroxime Sodium for Injection is consistent in clinical practice,while generic drugs are more economical.关键词
真实世界研究/注射用头孢呋辛钠/仿制药/原研药/有效性/安全性/经济性Key words
real world study/Cefuroxime Sodium for Injection/generic drug/original-patented drug/clinical efficacy/safety/economy分类
医药卫生引用本文复制引用
李明芳,李承铖,赵营莉,单亮,左东泽,刘建军..仿制与原研注射用头孢呋辛钠治疗儿童支气管肺炎疗效、安全性及经济性比较[J].中国药业,2024,33(2):110-113,4.基金项目
安徽省卫生健康委员会项目[AHWJ2023BAc20099] （）
蚌埠医学院自然科学类项目[BYKY2019304ZD]. （）
