中国药业2024，Vol.33Issue(2)：128,后插1-后插4,5.DOI:10.3969/j.issn.1006-4931.2024.02.032
基于Beers标准的某院高血压并脑梗死老年患者潜在不适当用药分析
Analysis of Potentially Inappropriate Medication in Elderly Patients with Hypertension and Cerebral Infarction Based on Beers Criteria in a Hospital
摘要
Abstract
Objective To ensure the medication safety of elderly patients with hypertension and cerebral infarction.Methods The medication orders of elderly patients(≥65 years)with hypertension and cerebral infarction were extracted by the hospital information system in 2020.The occurence of potentially inappropriate medication(PIM)in patients was analyzed by the American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults(hereinafter referred to as the Beers Criteria),and the independent risk factors for PIM were analyzed by the multivariate Logistic regression analysis.Results A total of 115 patients were included,of which 109 patients(94.78%)had PIM,involving 334 cases.The incidence of PIM related to careless medication in elderly patients was the highest(180 cases,53.89%),followed by drug-related PIM(121 cases,36.23%).Aspirin Enteric-Coated Tablets(78 cases,23.35%),Furosemide(31 cases,9.28%),Spironolactone Tablets(29 cases,8.68%)were related to a high frequency of PIM.Twenty-one cases of PIM were related to disease or symptoms,of which 95.23%cases had a history of renal insufficiency.Twelve cases of PIM involved drug interactions,mainly including the combination of nonsteroidal anti-inflammatory drugs and corticosteroids,the combination of two renin-angiotensin system(RAS)inhibitors,the combination of one RAS inhibitor and potassium sparing diuretics.Multivariate Logistic regression analysis showed that only medication>nine varieties was the independent risk factor for PIM in patients[OR = 10.056,95%CI(3.053,33.117),P<0.001].Conclusion The incidence of PIM in elderly patients with hypertension and cerebral infarction is high,and it is suggested that pharmacists should determine medication safety risks based on the Beers Criteria and clinical practice.关键词
Beers标准/高血压/脑梗死/老年患者/潜在不适当用药/药学服务Key words
Beers Criteria/hypertension/cerebral infarction/elderly patient/potentially inappropriate medication/pharmaceutical care分类
医药卫生引用本文复制引用
宦娣,叶根深,李佳会,刘忠明..基于Beers标准的某院高血压并脑梗死老年患者潜在不适当用药分析[J].中国药业,2024,33(2):128,后插1-后插4,5.基金项目
安徽省蚌埠市科技创新指导类项目[20210304]. （）
