中国真菌学杂志2023，Vol.18Issue(5)：406-410,5.
基于高通量测序技术对母亲和新生儿真菌群落结构关系的研究
The correlations of fungal community structure between mothers and neonates based on high-throughput se-quencing techniques
摘要
Abstract
Objective The study was designed to identify the fungal diversity and to analyze the correlations of fungal com-munity structure between mothers and neonates.Methods Twenty-five pregnant women and their neonates were recruited in this study,and the samples were collected from maternal oral cavity,amniotic fluid,placenta and neonatal oral cavity.High-throughput amplicon sequencing was performed using the Illumina MiSeq platform.Results The predominant phyla were Ascomycota and Basidiomycota,and the most frequently shared genera in five groups,including Rhodotorula,Davi-diella,Meyerozyma,Malassezia and Cryptococcus.The structure of the neonatal oral fungal mycobiome is similar to that of the maternal mycobiome.Conclusions The neonatal oral fungal colonization occurs before birth,and the maternal oral fungi community may cross the placenta to reach the amniotic fluid and eventually colonized the neonatal oral cavity.关键词
新生儿/母亲/真菌/高通量测序/群落结构Key words
neonate/mothers/fungi/high-throughput sequencing/community structure分类
医药卫生引用本文复制引用
郑欣,程旭梅,雷胜男,周建业,李志强..基于高通量测序技术对母亲和新生儿真菌群落结构关系的研究[J].中国真菌学杂志,2023,18(5):406-410,5.基金项目
中央高校基本科研业务费项目(31920180031) （31920180031）
国家自然科学基金项目(31760159/C0309) （31760159/C0309）
